{"id":"W2140841327","doi":"10.1158/0008-5472.can-08-4766","title":"Src Stimulates Fibroblast Growth Factor Receptor-2 Shedding by an ADAM15 Splice Variant Linked to Breast Cancer","year":2009,"lang":"en","type":"article","venue":"Cancer Research","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Biotechnology and Biological Sciences Research Council; University of California, San Francisco; Wellcome Trust","keywords":"Proto-oncogene tyrosine-protein kinase Src; Cancer research; Biology; Breast cancer; Cancer; Src family kinase; splice; Cell biology; Kinase; Biochemistry; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00151997,0.0004825706,0.0007319732,0.0007059876,0.0005125802,0.0002390697,0.001018479,0.0003637274,0.01088706],"category_scores_gemma":[0.0004465073,0.0004332771,0.0001426875,0.002332742,0.0002799784,0.0004308898,0.000300578,0.002023739,0.0004985155],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002847786,"about_ca_system_score_gemma":0.002146798,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009836718,"about_ca_topic_score_gemma":0.0005236575,"domain_scores_codex":[0.9923473,0.0004656325,0.0006007027,0.001457061,0.002836662,0.002292671],"domain_scores_gemma":[0.9944994,0.0002910066,0.00007927942,0.001141503,0.001901242,0.002087525],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002012728,0.000446948,0.005149509,0.0003948763,0.0001328702,0.0001273247,0.001678935,0.0001866708,0.7312269,0.0001107675,0.1956571,0.06287546],"study_design_scores_gemma":[0.01574663,0.01380453,0.3182608,0.01309874,0.0001937568,0.0003840006,0.002659538,0.006350045,0.3558371,0.0008601232,0.2683405,0.004464179],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9557732,0.002435918,0.0002173973,0.03434104,0.0003772627,0.002880553,0.001528684,0.0003197672,0.002126141],"genre_scores_gemma":[0.9883355,0.001745116,0.0006615403,0.001555214,0.002055779,0.0005981228,0.00009069163,0.0001686682,0.004789392],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3753897,"threshold_uncertainty_score":0.9998119,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08792739972269824,"score_gpt":0.4507606643172731,"score_spread":0.3628332645945748,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}