{"id":"W2140841583","doi":"10.1210/me.2008-0368","title":"PLC-γ1 and Rac1 Coregulate EGF-Induced Cytoskeleton Remodeling and Cell Migration","year":2009,"lang":"en","type":"article","venue":"Molecular Endocrinology","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":101,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Alberta Heritage Foundation for Medical Research","keywords":"Guanine nucleotide exchange factor; Cell biology; RAC1; Biology; GTPase; Actin cytoskeleton; Pleckstrin homology domain; Cytoskeleton; Epidermal growth factor; Rac GTP-Binding Proteins; Proto-oncogene tyrosine-protein kinase Src; SH3 domain; Actin remodeling; Cell migration; Signal transduction; Cell; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001229412,0.0003315538,0.0001402272,0.0003230491,0.0001747175,0.0002534355,0.0001636714,0.0002038609,0.00145871],"category_scores_gemma":[0.0001180251,0.0001285605,0.0001828346,0.0001462131,0.0002382796,0.000169871,0.0002461922,0.0004290608,0.0004785136],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004242846,"about_ca_system_score_gemma":0.0002311734,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005014483,"about_ca_topic_score_gemma":0.0007132337,"domain_scores_codex":[0.9998887,0.00002038033,0.000005660153,0.00001520132,0.00002396098,0.0000461334],"domain_scores_gemma":[0.9999423,0.000009180522,0.00001604294,0.00000653984,0.00000566415,0.00002013352],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002941944,0.0000557735,0.0002145308,0.00005161611,0.000005865179,0.0001127651,0.00002995505,0.0001260088,0.9921449,0.0007516646,0.0001409655,0.006071769],"study_design_scores_gemma":[0.00009919103,0.0003616933,0.01676646,0.00001745739,0.00001720589,0.0007149281,0.00007473842,0.001226279,0.9692648,0.0004731689,0.0109762,0.00000787276],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9872016,0.005080531,0.001965783,0.0003486746,0.00002835915,0.00003370447,0.0001221197,0.0000624067,0.005156743],"genre_scores_gemma":[0.9926229,0.001695746,0.00134591,0.0001111086,0.00001616273,0.00003871373,0.0002593178,0.00001130904,0.003898876],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00145871,"threshold_uncertainty_score":0.004879832,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008731549357641841,"score_gpt":0.2364576603793651,"score_spread":0.2277261110217233,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}