{"id":"W2140841583","doi":"10.1210/me.2008-0368","title":"PLC-γ1 and Rac1 Coregulate EGF-Induced Cytoskeleton Remodeling and Cell Migration","year":2009,"lang":"en","type":"article","venue":"Molecular Endocrinology","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":101,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Alberta Heritage Foundation for Medical Research","keywords":"Guanine nucleotide exchange factor; Cell biology; RAC1; Biology; GTPase; Actin cytoskeleton; Pleckstrin homology domain; Cytoskeleton; Epidermal growth factor; Rac GTP-Binding Proteins; Proto-oncogene tyrosine-protein kinase Src; SH3 domain; Actin remodeling; Cell migration; Signal transduction; Cell; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008212397,0.0002031853,0.000182678,0.00008691543,0.0001068925,0.00003158831,0.00008276751,0.0001684254,0.000004971469],"category_scores_gemma":[0.00003779888,0.000213705,0.00005497145,0.00006679523,0.00006108829,0.000006867311,0.00007431759,0.0001158895,0.000003175761],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001041434,"about_ca_system_score_gemma":0.00003031445,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002084107,"about_ca_topic_score_gemma":0.00001045518,"domain_scores_codex":[0.9987814,0.00008948953,0.0002212343,0.000473791,0.00009804856,0.0003360593],"domain_scores_gemma":[0.9994692,0.000006367484,0.00008568919,0.0002751641,0.00006082975,0.000102815],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005738418,0.00002451726,0.0001487,0.00001135992,0.00001090894,0.00003333286,0.00002746465,0.0001420496,0.9769976,0.000693063,0.00005044184,0.0218032],"study_design_scores_gemma":[0.0009800991,0.0003936233,0.001914265,0.00001249677,0.00002608395,0.0001778777,0.00002388239,0.002035069,0.9870468,0.000988488,0.006134541,0.0002668098],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9848542,0.002898772,0.01052532,0.0009450554,0.00004712863,0.0002337925,0.000002776208,0.00003245704,0.0004604612],"genre_scores_gemma":[0.9959612,0.0002962529,0.002606482,0.0008136734,0.00007200963,0.000009889073,0.00006871461,0.00001941284,0.0001523961],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02153639,"threshold_uncertainty_score":0.8714637,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008731549357641841,"score_gpt":0.2364576603793651,"score_spread":0.2277261110217233,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}