{"id":"W2140853356","doi":"10.3390/genes6030641","title":"Chromatin Dynamics in Lineage Commitment and Cellular Reprogramming","year":2015,"lang":"en","type":"review","venue":"Genes","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Ontario Ministry of Research and Innovation; Canadian Institutes of Health Research","keywords":"Chromatin; Reprogramming; Biology; ChIA-PET; Histone; Cell biology; Bivalent chromatin; Induced pluripotent stem cell; Embryonic stem cell; Cellular differentiation; Gene; Transcription factor; Genome; Chromatin remodeling; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005002501,0.0002809962,0.0006515775,0.0001018616,0.00003512279,0.00004152224,0.0002716538,0.0003563062,0.000004140974],"category_scores_gemma":[0.0000352566,0.0002455122,0.0001302132,0.0001288775,0.00006762103,0.000001495997,0.000448882,0.0001754115,0.00002077856],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000112683,"about_ca_system_score_gemma":0.000169415,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003660663,"about_ca_topic_score_gemma":0.00009853989,"domain_scores_codex":[0.9983897,0.0001977357,0.0003783186,0.0005329672,0.0001834099,0.0003179122],"domain_scores_gemma":[0.9991469,0.00001449686,0.0001295049,0.0005488263,0.00004566264,0.0001145803],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000003906596,0.00004624352,0.00008545526,0.004544837,0.00006082809,0.00004315272,0.000006725518,0.000001553975,0.0003872206,0.000006703922,0.0002878519,0.9945255],"study_design_scores_gemma":[0.0001669538,0.0000924228,0.000001190033,0.0007518205,0.00005380421,0.00002455454,0.00002731821,0.0001196086,0.0005865884,0.000003395016,0.9979229,0.0002494173],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001180955,0.9975299,0.00006835733,0.000008861388,0.00008756037,0.000679756,0.00004085266,0.000009646178,0.0003940963],"genre_scores_gemma":[0.00007171091,0.9963845,0.0007388514,0.00000691131,0.00017683,0.0001196484,0.001206446,0.00004900896,0.001246115],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9976351,"threshold_uncertainty_score":0.9999997,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04524727265871741,"score_gpt":0.3378935037155765,"score_spread":0.2926462310568591,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}