{"id":"W2140928268","doi":"10.1002/ddr.3000","title":"Design, syntheses, and evaluation of novel 1,1‐dihalo‐2,3‐diphenylcyclopropanes as potential cyclooxygenase‐2 (COX‐2) inhibitors with analgesic‐antiinflammatory activity","year":2002,"lang":"en","type":"article","venue":"Drug Development Research","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Analgesic; Chemistry; Cyclooxygenase; Pharmacology; In vivo; Stereochemistry; Carrageenan; Potency; Aspirin; Celecoxib; Substituent; Enzyme; In vitro; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000162255,0.0004858776,0.0002840883,0.0002519168,0.0001520667,0.000237779,0.0003165129,0.0002271991,0.001616334],"category_scores_gemma":[0.00008943168,0.0002140985,0.0002180773,0.0001852024,0.0001550419,0.000207423,0.0001490737,0.0003674867,0.0004247481],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002323651,"about_ca_system_score_gemma":0.0004661066,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003577887,"about_ca_topic_score_gemma":0.001021417,"domain_scores_codex":[0.99993,0.00001158689,0.00000645465,0.00001457687,0.00001943773,0.00001794317],"domain_scores_gemma":[0.9999387,0.000005325206,0.00001940552,0.000004535255,0.00001292284,0.00001913555],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001455038,0.0001481581,0.00007397917,0.0002010982,0.0000100415,0.00009264177,0.00001443756,0.0005420656,0.9933385,0.0002634079,0.0001234568,0.005046802],"study_design_scores_gemma":[0.0002655879,0.003422976,0.001135469,0.00001846542,0.0000490354,0.0002650667,0.00002576707,0.0008701751,0.9831547,0.00007345314,0.01069974,0.00001958561],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9568273,0.01271307,0.01943274,0.0003101563,0.0001847188,0.001281512,0.001696507,0.0001897206,0.00736434],"genre_scores_gemma":[0.95546,0.01157073,0.02329512,0.0002508245,0.00006784173,0.0008528664,0.001583247,0.0000226844,0.006896768],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001616334,"threshold_uncertainty_score":0.005407155,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0932864652399126,"score_gpt":0.3312999455982413,"score_spread":0.2380134803583287,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}