{"id":"W2141004462","doi":"10.1158/1538-7445.sabcs14-p4-11-11","title":"Abstract P4-11-11: CADER prognostic gene signature for disease free survival in hormone receptor positive breast cancer: NCIC CTG MA.12 phase III placebo-controlled tamoxifen trial","year":2015,"lang":"en","type":"article","venue":"Cancer Research","topic":"Breast Cancer Treatment Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Queen's University","funders":"","keywords":"Medicine; Oncology; Internal medicine; Breast cancer; Tamoxifen; Hormone receptor; Clinical endpoint; Cancer; Proportional hazards model; Gynecology; Placebo; Gene signature; Randomized controlled trial; Pathology; Biology; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001195567,0.0009007604,0.001194092,0.0003604962,0.0002258621,0.0006692433,0.0006727804,0.001063967,0.00440492],"category_scores_gemma":[0.001216599,0.0001668561,0.0006876139,0.0003323098,0.0005947285,0.000514364,0.0002195854,0.001902955,0.0005975216],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006844932,"about_ca_system_score_gemma":0.0006588095,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007615663,"about_ca_topic_score_gemma":0.002162356,"domain_scores_codex":[0.9996575,0.0002153062,0.00001485473,0.00004512594,0.00002826779,0.00003893648],"domain_scores_gemma":[0.9993018,0.0002046835,0.0001925201,0.00006168414,0.00004428702,0.0001950643],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9178928,0.00458534,0.007501592,0.000734892,0.001570339,0.00009989938,0.00005004245,0.0009615342,0.01004871,0.0002335035,0.004408501,0.05191291],"study_design_scores_gemma":[0.8333716,0.1265397,0.03034767,0.0001170158,0.002027479,0.0001888742,0.00002707027,0.001462935,0.002314765,0.0004256794,0.003139359,0.00003793513],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9850696,0.007376925,0.0003375464,0.001350291,0.0001297405,0.00108524,0.001594541,0.00009902876,0.002957135],"genre_scores_gemma":[0.9899275,0.001557038,0.0006969357,0.0009648314,0.0002423254,0.001402162,0.001676913,0.00001406348,0.003518278],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00440492,"threshold_uncertainty_score":0.01473594,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04520311746771554,"score_gpt":0.3722970663252771,"score_spread":0.3270939488575615,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}