{"id":"W2141008336","doi":"10.1101/gad.255109.114","title":"Myc and SAGA rewire an alternative splicing network during early somatic cell reprogramming","year":2015,"lang":"en","type":"article","venue":"Genes & Development","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":92,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Human Genome Research Institute; Canadian Institutes of Health Research; U.S. Public Health Service; Cancer Prevention and Research Institute of Texas; Ontario Ministry of Economic Development and Innovation; National Cancer Institute; Cancer Center for Detection and Prevention; National Institutes of Health; National Institute of General Medical Sciences; Stem Cell Network","keywords":"Reprogramming; Biology; Induced pluripotent stem cell; Somatic cell; Epigenetics; Embryonic stem cell; Cell biology; Cell potency; Genetics; Cell; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001576545,0.0002088401,0.000150253,0.0001985928,0.0001082997,0.0003241734,0.0001864975,0.0001872583,0.000617378],"category_scores_gemma":[0.000122937,0.0001918375,0.0001796321,0.0001307795,0.0001889813,0.0002519954,0.0003046548,0.0002913029,0.0002559645],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003388709,"about_ca_system_score_gemma":0.0001655732,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002564865,"about_ca_topic_score_gemma":0.0007814413,"domain_scores_codex":[0.9998399,0.00002248401,0.00001247362,0.00003718703,0.0000592573,0.00002869707],"domain_scores_gemma":[0.9999299,0.0000116925,0.00002235812,0.00001146382,0.000009243064,0.00001527249],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003124932,0.000005092696,0.0002779476,0.00001149872,0.000002296303,0.00003920693,0.000008155618,0.00009985847,0.9967962,0.0004165405,0.00001790029,0.002294155],"study_design_scores_gemma":[0.00000925618,0.00006974598,0.005829004,0.000005810815,0.00001608378,0.0002909183,0.000021347,0.002875937,0.9867423,0.0003580831,0.003777239,0.000004187269],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.979793,0.001491965,0.01448366,0.0001139878,0.0000285341,0.00002686899,0.0002269138,0.0001948543,0.003640323],"genre_scores_gemma":[0.9931808,0.000432945,0.004074934,0.00005429376,0.000006349184,0.00001603213,0.0002449225,0.00002904373,0.001960774],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000617378,"threshold_uncertainty_score":0.002458692,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02622169978202911,"score_gpt":0.2606246978239832,"score_spread":0.2344029980419541,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}