{"id":"W2141008336","doi":"10.1101/gad.255109.114","title":"Myc and SAGA rewire an alternative splicing network during early somatic cell reprogramming","year":2015,"lang":"en","type":"article","venue":"Genes & Development","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":92,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Human Genome Research Institute; Canadian Institutes of Health Research; U.S. Public Health Service; Cancer Prevention and Research Institute of Texas; Ontario Ministry of Economic Development and Innovation; National Cancer Institute; Cancer Center for Detection and Prevention; National Institutes of Health; National Institute of General Medical Sciences; Stem Cell Network","keywords":"Reprogramming; Biology; Induced pluripotent stem cell; Somatic cell; Epigenetics; Embryonic stem cell; Cell biology; Cell potency; Genetics; Cell; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004640371,0.0001865064,0.0001565436,0.00004582807,0.0001797679,0.00007586075,0.0002108028,0.00009186567,0.000005056161],"category_scores_gemma":[0.00001931729,0.0001822341,0.00002725731,0.00009652935,0.00004036891,0.00001044223,0.0003938115,0.00008556285,0.00002128687],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005749793,"about_ca_system_score_gemma":0.0001541447,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004853669,"about_ca_topic_score_gemma":0.000050895,"domain_scores_codex":[0.9983613,0.00008298189,0.0002596487,0.0005194808,0.0002850458,0.0004915107],"domain_scores_gemma":[0.9992021,0.000007004198,0.00008645355,0.0003315487,0.0001018635,0.0002709947],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000191409,0.0001385216,0.1085585,0.0002105068,0.0001782054,0.0001064987,0.003627315,0.001627075,0.7926723,0.000009982651,0.0001842917,0.09249549],"study_design_scores_gemma":[0.001373163,0.0003054472,0.07127737,0.000102846,0.0000189003,0.00006725464,0.0006943211,0.0003581986,0.903283,0.0001007324,0.02177591,0.0006428629],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958265,0.002427606,0.000703515,0.00002792194,0.0001206858,0.0002820705,9.807005e-7,0.00002361377,0.0005871117],"genre_scores_gemma":[0.9812878,0.0002362048,0.01666555,0.00003811148,0.0002803449,0.00005181977,0.00004517702,0.00003464363,0.001360293],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1106107,"threshold_uncertainty_score":0.743129,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02622169978202911,"score_gpt":0.2606246978239832,"score_spread":0.2344029980419541,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}