{"id":"W2141030054","doi":"10.1093/brain/awv102","title":"Fibroblast growth factor signalling in multiple sclerosis: inhibition of myelination and induction of pro-inflammatory environment by FGF9","year":2015,"lang":"en","type":"article","venue":"Brain","topic":"Fibroblast Growth Factor Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Medical Research Council; Schweizerische Multiple Sklerose Gesellschaft; Bundesministerium für Bildung und Forschung; Deutsche Forschungsgemeinschaft; Austrian Science Fund; Multiple Sclerosis Society","keywords":"Remyelination; Multiple sclerosis; Oligodendrocyte; Biology; Myelin; Cell biology; FGF9; Microglia; Astrocyte; Fibroblast growth factor; Chemokine; Immunology; Neuroscience; Cancer research; Inflammation; Central nervous system; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002561586,0.00009247081,0.0001064887,0.00008579931,0.000015638,0.000006298639,0.00005107645,0.0001274243,0.000004810428],"category_scores_gemma":[0.0001824453,0.00009685822,0.00002461563,0.00006403086,0.00009561035,0.00001467464,0.00007361265,0.00007488796,0.00000165072],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003412008,"about_ca_system_score_gemma":0.00004044619,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003990598,"about_ca_topic_score_gemma":0.00001213051,"domain_scores_codex":[0.9991208,0.00009531838,0.0002422987,0.0002093799,0.0002015659,0.0001306075],"domain_scores_gemma":[0.9996499,0.00001899441,0.0001109616,0.0001003651,0.00005873774,0.00006097335],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008807205,0.00006446724,0.007808797,0.0000946107,0.00000838473,2.694552e-7,0.00020266,0.00008490251,0.9907963,0.00001245582,0.0002745911,0.0005644509],"study_design_scores_gemma":[0.0009153272,0.0003237028,0.02610395,0.0001262171,0.000001445836,0.000001037337,0.0001485743,0.0002268678,0.9719131,0.00005362949,0.00009690846,0.00008925344],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985947,0.000131252,0.0008450219,0.00008931914,0.00001069176,0.0002607187,0.00004101468,0.000004129859,0.00002312649],"genre_scores_gemma":[0.9994351,0.00002473558,0.0003198329,0.000007088599,0.00003048915,0.00001927354,0.0001211422,0.00001424006,0.00002807772],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01888325,"threshold_uncertainty_score":0.3949764,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03625317629038102,"score_gpt":0.2338920491421987,"score_spread":0.1976388728518176,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}