{"id":"W2141035496","doi":"10.1016/s0002-9440(10)61702-6","title":"PTEN Is a Target of Chromosome 10q Loss in Anaplastic Oligodendrogliomas and PTEN Alterations Are Associated with Poor Prognosis","year":2001,"lang":"en","type":"article","venue":"American Journal Of Pathology","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":165,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"National Cancer Institute; Medical Research Council; National Institutes of Health","keywords":"PTEN; Cancer research; Oligodendroglioma; Biology; Glioma; Tumor suppressor gene; Loss of heterozygosity; Carcinogenesis; Cancer; Allele; Gene; Genetics; Astrocytoma; PI3K/AKT/mTOR pathway; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002127541,0.000147621,0.0004137486,0.0001709619,0.00003249367,0.000009569387,0.0001580211,0.0000847569,0.00002371188],"category_scores_gemma":[0.0001596044,0.0001259016,0.00006494195,0.0003197018,0.0004310094,0.000009699786,0.00004093638,0.0001541862,6.846319e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003358585,"about_ca_system_score_gemma":0.0001262454,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001637434,"about_ca_topic_score_gemma":0.00008015495,"domain_scores_codex":[0.9988471,0.0001549105,0.0003919644,0.0002162781,0.000143447,0.0002462653],"domain_scores_gemma":[0.9988022,0.0000459343,0.0006996437,0.000124924,0.0002367125,0.00009061708],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006805568,0.0003660761,0.653062,0.0000178794,0.0003657459,0.001783561,0.0006186887,0.0006477085,0.3395329,0.00001099915,0.0003667613,0.002547155],"study_design_scores_gemma":[0.01140034,0.03604741,0.5577545,0.001053553,0.000653116,0.02309256,0.002414074,0.00148844,0.3604259,0.0004675505,0.003503226,0.001699296],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976746,0.0006408117,0.0009830876,0.0004601507,0.00005483883,0.0000787786,0.00004758295,0.000003259941,0.00005684005],"genre_scores_gemma":[0.9980924,0.000199605,0.001207489,0.0003298245,0.00009855603,0.000009794136,0.00001238409,0.00002082161,0.00002912733],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09530754,"threshold_uncertainty_score":0.5134116,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007980397052114901,"score_gpt":0.2467455498168671,"score_spread":0.2387651527647522,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}