{"id":"W2141078296","doi":"10.1128/mbio.01625-14","title":"Human Factor H (FH) Impairs Protective Meningococcal Anti-FHbp Antibody Responses and the Antibodies Enhance FH Binding","year":2014,"lang":"en","type":"article","venue":"mBio","topic":"Bacterial Infections and Vaccines","field":"Immunology and Microbiology","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Research Resources; National Institute of Allergy and Infectious Diseases; National Institutes of Health","keywords":"Immunogenicity; Antibody; Antigen; Epitope; Biology; Genetically modified mouse; Transgene; Complement system; Virology; Mutant; Microbiology; Complement factor B; Antiserum; Molecular biology; Immunology; Gene; Biochemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002161486,0.0007073831,0.0002564733,0.000208026,0.00009224116,0.0001959903,0.0002356244,0.0004902773,0.001957165],"category_scores_gemma":[0.0001563768,0.0001314029,0.0001784938,0.00006962985,0.0003261458,0.0001530446,0.0001594837,0.0006822899,0.0003721495],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003795164,"about_ca_system_score_gemma":0.0001819194,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004857176,"about_ca_topic_score_gemma":0.000550096,"domain_scores_codex":[0.9997262,0.00005997735,0.00002091223,0.00004480647,0.00006512766,0.00008303621],"domain_scores_gemma":[0.9998392,0.00003442724,0.00005325161,0.00001516454,0.00001386823,0.00004406423],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006281399,0.0001478537,0.0003996052,0.00003922914,0.000007870896,0.00003721135,0.000007510533,0.00003446802,0.9973008,0.00003532925,0.0000442701,0.001317734],"study_design_scores_gemma":[0.00005868179,0.002198878,0.007872338,0.000009961419,0.00002161038,0.0002664219,0.00001941014,0.0003544065,0.9881569,0.00002402471,0.001014351,0.000003176558],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977048,0.0006878373,0.0006430479,0.00008406035,0.00003338254,0.00001947123,0.0001320847,0.00006074107,0.0006346524],"genre_scores_gemma":[0.996405,0.0003142956,0.0008920977,0.00008399849,0.00001697126,0.0000279577,0.0002104896,0.00001120125,0.002037904],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001957165,"threshold_uncertainty_score":0.006547391,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01331186713122575,"score_gpt":0.2926273145306487,"score_spread":0.2793154473994229,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}