{"id":"W2141101470","doi":"10.1523/jneurosci.23-17-06810.2003","title":"The Human Immunodeficiency Virus-1 Protein Tat and Its Discrete Fragments Evoke Selective Release of Acetylcholine from Human and Rat Cerebrocortical Terminals through Species-Specific Mechanisms","year":2003,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Università degli Studi di Genova","keywords":"Dantrolene; Acetylcholine; Synaptosome; Neurotransmitter; Metabotropic glutamate receptor; Glutamate receptor; Agonist; Metabotropic receptor; Chemistry; Ryanodine receptor; Free nerve ending; Biology; Receptor; Biochemistry; Pharmacology; Endocrinology; Calcium; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001138035,0.0003664063,0.0002218602,0.0001180261,0.0001044544,0.0001701165,0.0001769163,0.0003001596,0.0007696039],"category_scores_gemma":[0.0001325968,0.0001387872,0.0003545959,0.00009752224,0.0002230775,0.0001466441,0.0001907877,0.0004569039,0.0001677047],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001961909,"about_ca_system_score_gemma":0.0001387036,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004948659,"about_ca_topic_score_gemma":0.0009206724,"domain_scores_codex":[0.9998811,0.00001978154,0.00001099418,0.00002639222,0.00002481468,0.00003687854],"domain_scores_gemma":[0.9999353,0.00001525751,0.00001438733,0.0000112443,0.000005953665,0.00001779685],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001726924,0.00001351792,0.00005205649,0.00002686071,0.000005849685,0.00006162619,0.00001259866,0.00001200406,0.9992747,0.00002531166,0.000007414764,0.0003353907],"study_design_scores_gemma":[0.00002589485,0.001217517,0.006125798,0.000007128211,0.00003342205,0.0006257417,0.0000266943,0.0002916904,0.9908277,0.00002979001,0.0007843744,0.000004281753],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967778,0.001744455,0.0007846053,0.00002440096,0.00001498425,0.00001994732,0.00009863023,0.00002058231,0.000514594],"genre_scores_gemma":[0.9959142,0.001027459,0.00162567,0.00003947495,0.00001069081,0.00004375734,0.0002880047,0.000009745434,0.001041109],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007696039,"threshold_uncertainty_score":0.002574623,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03040091989148854,"score_gpt":0.2976522151894456,"score_spread":0.267251295297957,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}