{"id":"W2141108781","doi":"10.1517/17425255.4.10.1245","title":"A critical overview of the influence of inflammation and infection on P-glycoprotein expression and activity in the brain","year":2008,"lang":"en","type":"review","venue":"Expert Opinion on Drug Metabolism & Toxicology","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Nova Scotia Health Research Foundation","keywords":"P-glycoprotein; Inflammation; Blood–brain barrier; In vivo; Immunology; Transporter; Glycoprotein; Medicine; In vitro; Downregulation and upregulation; Neuroinflammation; Biology; Central nervous system; Pharmacology; Internal medicine; Drug resistance; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006664717,0.00131816,0.001801805,0.002698915,0.0002701068,0.000937165,0.0008630105,0.001239829,0.003056799],"category_scores_gemma":[0.0007378011,0.0003638456,0.0006862705,0.002526011,0.0003831575,0.0017925,0.0004064824,0.001471054,0.001942757],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001054281,"about_ca_system_score_gemma":0.001443337,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001393327,"about_ca_topic_score_gemma":0.002139446,"domain_scores_codex":[0.9997223,0.00005133384,0.00005887037,0.00004309932,0.00009876444,0.00002562235],"domain_scores_gemma":[0.9995832,0.0001562617,0.00005301606,0.00001031746,0.0001701117,0.00002706882],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001589639,0.00008625819,0.0002246805,0.03516218,0.0001579341,0.0008363904,0.00009920723,0.0004272096,0.005162163,0.002758265,0.08450914,0.8704176],"study_design_scores_gemma":[0.00002530126,0.0001780811,0.001614873,0.006291976,0.0002058455,0.002707601,0.00008642775,0.0001521877,0.001255686,0.001547944,0.9859035,0.00003070567],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000169626,0.9973266,0.0002407412,0.0005805405,0.0006116022,0.00001148678,0.0000362159,0.000009566662,0.001013624],"genre_scores_gemma":[0.0004991124,0.99783,0.0003307636,0.0003071704,0.0003933563,0.00001574389,0.00004917487,0.000001558797,0.0005732416],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003056799,"threshold_uncertainty_score":0.01022601,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04490207648889131,"score_gpt":0.3665675892566628,"score_spread":0.3216655127677714,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}