{"id":"W2141114384","doi":"10.4049/jimmunol.1402956","title":"Functional Analysis of a Complement Polymorphism (rs17611) Associated with Rheumatoid Arthritis","year":2015,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Medical Research Council; Versus Arthritis","keywords":"Complement component 5; Complement system; Single-nucleotide polymorphism; SNP; Rheumatoid arthritis; Immunology; Pathogenesis; Proteases; Synovial fluid; Arthritis; Alternative complement pathway; Elastase; Biology; Medicine; Gene; Genetics; Antibody; Enzyme; Genotype; Biochemistry; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001257059,0.0001637704,0.0007371539,0.0004722177,0.0001164414,0.00000631312,0.0004214952,0.00009164879,0.001622022],"category_scores_gemma":[0.0002335395,0.0001032386,0.0002179965,0.0005412388,0.0004309473,0.00007722798,0.0001126043,0.000263264,0.00004096546],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001178879,"about_ca_system_score_gemma":0.0002435851,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001845344,"about_ca_topic_score_gemma":0.0002144194,"domain_scores_codex":[0.997673,0.0009069076,0.0008880066,0.0001047449,0.000143114,0.0002841679],"domain_scores_gemma":[0.9972025,0.0005317962,0.001297324,0.0003245939,0.0006127965,0.00003100437],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.01733901,0.003741815,0.2783804,0.00002297691,0.1950074,0.0001007234,0.008739669,0.004710911,0.3661783,0.008458584,0.1100743,0.007245953],"study_design_scores_gemma":[0.02021268,0.00538122,0.9252704,0.0004643075,0.004845071,0.002221031,0.01004909,0.00004658353,0.01725388,0.0008250583,0.01287754,0.0005531828],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9780742,0.01960908,0.000696429,0.0006072518,0.0005849245,0.0001392692,0.00008096033,0.00001551001,0.0001924049],"genre_scores_gemma":[0.9993328,0.0002926126,0.0000241448,0.0000689376,0.00001532115,0.000004503068,0.00008945449,0.00001098524,0.0001611764],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6468899,"threshold_uncertainty_score":0.9992906,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03008991916543726,"score_gpt":0.2434513259536104,"score_spread":0.2133614067881732,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}