{"id":"W2141128064","doi":"10.1210/en.2005-0902","title":"Regulation of Hepatic Insulin-Like Growth Factor-Binding Protein-1 Gene Expression by Insulin: Central Role for Mammalian Target of Rapamycin Independent of Forkhead Box O Proteins","year":2006,"lang":"en","type":"article","venue":"Endocrinology","topic":"FOXO transcription factor regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"McGill University","keywords":"Internal medicine; Endocrinology; Insulin; Forkhead Transcription Factors; Insulin-like growth factor-binding protein; Biology; Binding protein; Insulin-like growth factor; Gene; Growth factor; Regulation of gene expression; Medicine; Receptor; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001118578,0.0004462133,0.0002808475,0.0002776548,0.0001733897,0.000301691,0.0001606829,0.0001713757,0.00103267],"category_scores_gemma":[0.00007180985,0.0001561565,0.0003377187,0.000189369,0.0002799018,0.0001867884,0.000180379,0.0004340343,0.0002610171],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003884147,"about_ca_system_score_gemma":0.0002804002,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000864637,"about_ca_topic_score_gemma":0.001472503,"domain_scores_codex":[0.9999087,0.00001008398,0.000008661787,0.00002809922,0.00002386479,0.00002053489],"domain_scores_gemma":[0.9999272,0.000008954789,0.00002368638,0.000007506987,0.000009847808,0.00002272147],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002199322,0.00002725605,0.0001977399,0.00007841597,0.000004780536,0.00005110591,0.00001099929,0.00003257763,0.9970524,0.00008813358,0.000085208,0.002151523],"study_design_scores_gemma":[0.00004555377,0.0004554788,0.03819705,0.00001763041,0.00003186641,0.0003160065,0.00005339353,0.0008162657,0.9542004,0.0001353002,0.005719272,0.00001191407],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9701827,0.01811737,0.005445003,0.0004350342,0.0001698136,0.00005995824,0.0009037452,0.0002963237,0.004390159],"genre_scores_gemma":[0.9820153,0.007653092,0.004314873,0.0001992336,0.00005077737,0.00008552285,0.0008086102,0.00003550593,0.004837147],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00103267,"threshold_uncertainty_score":0.003454685,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008237879561189819,"score_gpt":0.219253110568679,"score_spread":0.2110152310074892,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}