{"id":"W2141130828","doi":"10.4049/jimmunol.1202725","title":"Cytotoxic NKG2C+ CD4 T Cells Target Oligodendrocytes in Multiple Sclerosis","year":2013,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University; McGill University; Université de Montréal; Hôpital Notre-Dame; Montreal Neurological Institute and Hospital","funders":"Canadian Institutes of Health Research","keywords":"Cytotoxic T cell; Granzyme B; Perforin; CD8; Granzyme; Multiple sclerosis; Biology; Cell biology; Interleukin 21; Immunology; Myelin; Immune system; Chemistry; In vitro; Neuroscience; Central nervous system; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0005148973,0.0001769884,0.0003694682,0.0002930378,0.0001585577,0.00001775278,0.0004572974,0.0002448442,0.004410333],"category_scores_gemma":[0.0001546106,0.000117444,0.0001433055,0.0001727217,0.0002562529,0.0003171765,0.00009031669,0.0008947228,0.002756794],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009989744,"about_ca_system_score_gemma":0.00005345155,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003986819,"about_ca_topic_score_gemma":0.00002026343,"domain_scores_codex":[0.998172,0.000605998,0.0007012241,0.0001092758,0.00004185884,0.0003696594],"domain_scores_gemma":[0.9985808,0.0004616658,0.0004816128,0.0002718442,0.0001888742,0.00001522605],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004314011,0.0001433864,0.0006950893,0.000003313729,0.000181126,0.000002081695,0.0006062057,0.00007571564,0.9837291,0.00002854843,0.01282797,0.001276045],"study_design_scores_gemma":[0.002024142,0.0005176536,0.02309009,0.00005625184,0.00003118105,0.0005748409,0.001677344,0.00002468657,0.952207,0.0001289869,0.01952833,0.0001394617],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986288,0.007177579,0.0002401093,0.0007069064,0.004770537,0.0001957166,0.000001208778,0.0000195273,0.0006004487],"genre_scores_gemma":[0.9950347,0.001375129,0.00009164359,0.0003601907,0.00004716275,0.000009163836,0.000005522541,0.00001759384,0.003058903],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03152209,"threshold_uncertainty_score":0.9980197,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01878990087065797,"score_gpt":0.2060828954158796,"score_spread":0.1872929945452217,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}