{"id":"W2141135082","doi":"10.1128/aac.45.2.433-438.2001","title":"Mutant Prevention Concentrations of Fluoroquinolones for Clinical Isolates of <i>Streptococcus pneumoniae</i>","year":2001,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Pneumonia and Respiratory Infections","field":"Medicine","cited_by":314,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan; Royal University Hospital","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; Bayer","keywords":"Gatifloxacin; Moxifloxacin; Streptococcus pneumoniae; Levofloxacin; Trovafloxacin; Microbiology; Sparfloxacin; Mutant; Minimum inhibitory concentration; Medicine; Antibiotics; Pharmacology; Ciprofloxacin; Biology; Ofloxacin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009549843,0.0001022348,0.000314418,0.00004327421,0.00006531068,0.000006426597,0.00004078204,0.0001032148,0.00005425082],"category_scores_gemma":[0.00001483644,0.00008392032,0.0001839679,0.00009454659,0.0001564938,0.00004808954,0.000009253585,0.00006286223,0.000001209923],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006267867,"about_ca_system_score_gemma":0.00005415082,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007061101,"about_ca_topic_score_gemma":0.000004448755,"domain_scores_codex":[0.9991778,0.00002207053,0.0004459817,0.0001675482,0.0000515642,0.0001350716],"domain_scores_gemma":[0.9994729,0.00003902411,0.000185069,0.0001338187,0.0001130311,0.00005613821],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001324301,0.0007030856,0.416723,0.00008771945,0.0001648816,0.000001604862,0.0001288332,0.00000129705,0.5707712,0.00006301622,0.002148912,0.009074108],"study_design_scores_gemma":[0.009290735,0.002684492,0.4596753,0.0004339813,0.0003545845,0.0001069986,0.0001205298,0.0002067369,0.320567,0.0001893436,0.206073,0.0002973042],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960468,0.00003161885,0.0004617129,0.002559372,0.0001321317,0.0005854212,0.00002994747,0.00001899385,0.0001339589],"genre_scores_gemma":[0.9942636,0.00370964,0.0001067746,0.001569836,0.00009256844,0.00001186108,0.00001834375,0.00001372104,0.0002136186],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2502041,"threshold_uncertainty_score":0.3422171,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04553598527869962,"score_gpt":0.35835780988177,"score_spread":0.3128218246030704,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}