{"id":"W2141136499","doi":"10.1007/s00401-011-0938-4","title":"Presence of an oligodendroglioma-like component in newly diagnosed glioblastoma identifies a pathogenetically heterogeneous subgroup and lacks prognostic value: central pathology review of the EORTC_26981/NCIC_CE.3 trial","year":2012,"lang":"en","type":"article","venue":"Acta Neuropathologica","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":83,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre","funders":"National Cancer Institute; EORTC Charitable Trust; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Oligodendroglioma; Temozolomide; Oncology; Medicine; Internal medicine; Radiation therapy; Glioma; Glioblastoma; IDH1; Pathology; Astrocytoma; Biology; Cancer research; Mutation; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006722964,0.0003530011,0.00092413,0.0001408556,0.00006683381,0.00001586173,0.0003116617,0.0001547636,0.0000418693],"category_scores_gemma":[0.001403649,0.0002294204,0.0002468255,0.0004098113,0.0004712863,0.0001098114,0.0003166202,0.0002481726,0.00000341249],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003496563,"about_ca_system_score_gemma":0.00006136696,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002140538,"about_ca_topic_score_gemma":0.00002072949,"domain_scores_codex":[0.996255,0.001081046,0.0009389531,0.0005512402,0.0005140892,0.0006596661],"domain_scores_gemma":[0.9977872,0.0005421948,0.0004321288,0.0008400434,0.0001163362,0.000282141],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.009146005,0.0153253,0.5502487,0.003843259,0.0001323113,0.01199292,0.001756519,0.00003084522,0.3977248,0.000284496,0.0002431081,0.009271805],"study_design_scores_gemma":[0.01217285,0.00403718,0.9559993,0.0017025,0.0004752909,0.003968937,0.00004464972,0.00007007524,0.02108899,0.00004188275,0.0001577755,0.0002406386],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9852799,0.01124776,0.000003067285,0.0004050941,0.0004469215,0.002491109,0.00004448808,0.00003527835,0.00004635721],"genre_scores_gemma":[0.9921868,0.006710187,0.0002183919,0.0005837895,0.00008140426,0.0001650504,0.00001638768,0.00003267802,0.000005242713],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4057506,"threshold_uncertainty_score":0.9355494,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01655155683274321,"score_gpt":0.2668195034888354,"score_spread":0.2502679466560921,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}