{"id":"W2141136499","doi":"10.1007/s00401-011-0938-4","title":"Presence of an oligodendroglioma-like component in newly diagnosed glioblastoma identifies a pathogenetically heterogeneous subgroup and lacks prognostic value: central pathology review of the EORTC_26981/NCIC_CE.3 trial","year":2012,"lang":"en","type":"article","venue":"Acta Neuropathologica","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":83,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre","funders":"National Cancer Institute; EORTC Charitable Trust; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Oligodendroglioma; Temozolomide; Oncology; Medicine; Internal medicine; Radiation therapy; Glioma; Glioblastoma; IDH1; Pathology; Astrocytoma; Biology; Cancer research; Mutation; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005688501,0.0003802674,0.001389502,0.0003133149,0.000247684,0.000950725,0.0006310615,0.0005585398,0.001151589],"category_scores_gemma":[0.004581884,0.0001586144,0.001033038,0.0008473062,0.0005137672,0.0009118567,0.0003993595,0.001222013,0.0001555988],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008414625,"about_ca_system_score_gemma":0.0009306117,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001319025,"about_ca_topic_score_gemma":0.007581211,"domain_scores_codex":[0.9987603,0.0008006484,0.0001077333,0.0001217539,0.0001474315,0.00006211196],"domain_scores_gemma":[0.9970127,0.001597031,0.000512757,0.0003260525,0.0002878059,0.0002635696],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.2962007,0.0005600616,0.1925713,0.007534264,0.01677057,0.0002445517,0.0003221879,0.00150047,0.008361352,0.001883884,0.02109045,0.4529603],"study_design_scores_gemma":[0.0568188,0.03332541,0.7880524,0.003987619,0.04590173,0.001743764,0.0006150638,0.001955939,0.006899164,0.008091784,0.05243728,0.0001710368],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8366895,0.1454969,0.0007867278,0.004087853,0.0005255712,0.0002482263,0.003091138,0.00003334738,0.009040861],"genre_scores_gemma":[0.98236,0.01277871,0.0004807216,0.001116668,0.0002861403,0.00006544651,0.002483894,0.0000246345,0.0004038227],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005688501,"threshold_uncertainty_score":0.03008401,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01655155683274321,"score_gpt":0.2668195034888354,"score_spread":0.2502679466560921,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}