{"id":"W2141145973","doi":"10.1128/mcb.00866-07","title":"An EGR2/CITED1 Transcription Factor Complex and the 14-3-3σ Tumor Suppressor Are Involved in Regulating ErbB2 Expression in a Transgenic-Mouse Model of Human Breast Cancer","year":2007,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"14-3-3 protein interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; McGill University","funders":"National Cancer Institute; Natural Sciences and Engineering Research Council of Canada; McGill University Health Centre; Canadian Institutes of Health Research; Canadian Breast Cancer Research Alliance; McGill University; U.S. Department of Defense","keywords":"Biology; Transcription factor; Chromatin immunoprecipitation; Cancer research; Downregulation and upregulation; Coactivator; Promoter; Tumor suppressor gene; Molecular biology; Gene expression; Gene; Carcinogenesis; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003312886,0.0002190414,0.0003136982,0.0001268637,0.00008483381,0.0000163812,0.0001716332,0.0002292798,0.00001938851],"category_scores_gemma":[0.00001879442,0.0001775377,0.00008680848,0.00009582374,0.0002950127,0.00001271021,0.00005022508,0.0002104569,1.287039e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001982719,"about_ca_system_score_gemma":0.00002514415,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004163011,"about_ca_topic_score_gemma":0.001704823,"domain_scores_codex":[0.9984377,0.0002747535,0.0004311615,0.0004605415,0.00008629359,0.0003095462],"domain_scores_gemma":[0.9993722,0.00001748923,0.0001502872,0.0003174965,0.00006531118,0.00007715337],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005406973,0.0001026423,0.005792418,0.00004257221,0.00002343672,0.000003120233,0.0004394377,0.0002999054,0.9922261,0.0001343143,0.000002936654,0.0003924484],"study_design_scores_gemma":[0.002520223,0.0001297304,0.006189519,0.00005258862,0.00001835754,0.000006806376,0.0003375601,0.00226516,0.9879948,0.0002400179,0.00003745634,0.0002077968],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9857971,0.0008248361,0.01257581,0.0001281293,0.0000325885,0.0004477616,0.0001464035,0.00000913395,0.00003824473],"genre_scores_gemma":[0.9990209,0.00007098404,0.0004533287,0.0001442894,0.00003290226,0.00006035142,0.0001683685,0.00002809196,0.00002075025],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01322384,"threshold_uncertainty_score":0.7239776,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0206976344636475,"score_gpt":0.2779299703721729,"score_spread":0.2572323359085255,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}