{"id":"W2141156902","doi":"10.1158/0008-5472.can-07-1388","title":"Tobacco Smoke Induces Urokinase-Type Plasminogen Activator and Cell Invasiveness: Evidence for an Epidermal Growth Factor Receptor–Dependent Mechanism","year":2007,"lang":"en","type":"article","venue":"Cancer Research","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Cancer Institute; National Heart, Lung, and Blood Institute","keywords":"MAPK/ERK pathway; Urokinase receptor; Cancer research; Extracellular matrix; Cell migration; Plasminogen activator; Kinase; Epidermal growth factor; Cell biology; Epidermal growth factor receptor; Plasmin; Protein kinase A; Biology; Chemistry; Cell; Receptor; Biochemistry; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002137469,0.0004952885,0.0002664494,0.0003762885,0.0001626979,0.0002386843,0.0001930914,0.0004245765,0.001679747],"category_scores_gemma":[0.00009761538,0.0002277758,0.0008555799,0.0002360937,0.0002134046,0.0002356242,0.0002560726,0.0004865002,0.0003736631],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002163835,"about_ca_system_score_gemma":0.0002347058,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006741979,"about_ca_topic_score_gemma":0.0009939654,"domain_scores_codex":[0.9998512,0.00002059649,0.00001474275,0.00001936387,0.00005434116,0.00003966603],"domain_scores_gemma":[0.9998746,0.00002462751,0.00002964476,0.00002056668,0.0000207695,0.00002980896],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001730717,0.0001806913,0.00125617,0.00009264146,0.00002413534,0.0003103549,0.00002669805,0.00001914947,0.9958325,0.00009179095,0.00004097346,0.00195179],"study_design_scores_gemma":[0.00006377839,0.001150053,0.08981696,0.0000147861,0.00007384916,0.00151021,0.00007059672,0.0007864708,0.9042497,0.0001542804,0.002096118,0.00001314071],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9889166,0.006868966,0.0018161,0.000154993,0.00006303181,0.00008762617,0.0002137258,0.00006697754,0.001811932],"genre_scores_gemma":[0.9916488,0.003584605,0.001161001,0.00009796039,0.00003707478,0.0000924237,0.0004903304,0.000009016083,0.002878785],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001679747,"threshold_uncertainty_score":0.005619347,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1491285347053122,"score_gpt":0.3955531343618153,"score_spread":0.2464245996565031,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}