{"id":"W2141162694","doi":"10.1128/aac.49.4.1529-1541.2005","title":"Expression of<i>ccaR</i>, Encoding the Positive Activator of Cephamycin C and Clavulanic Acid Production in<i>Streptomyces clavuligerus</i>, Is Dependent on<i>bldG</i>","year":2005,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Directorate for Biological Sciences; Fondation pour la Recherche Médicale; University of Alberta","keywords":"Streptomyces clavuligerus; Streptomyces coelicolor; Open reading frame; Biology; Streptomyces; Gene; Regulator gene; Biochemistry; Genetics; Regulation of gene expression; Mutant; Peptide sequence; Actinomycetales; Bacteria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001991216,0.000209947,0.0003756597,0.00009521872,0.00009083453,0.00001783016,0.00009064173,0.0001198913,0.00006970107],"category_scores_gemma":[0.00002405041,0.0001306924,0.00007793086,0.0001605749,0.0001490642,0.0001224675,0.00004293627,0.0002003355,0.000001562105],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002858629,"about_ca_system_score_gemma":0.00002836661,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000533223,"about_ca_topic_score_gemma":0.000009458603,"domain_scores_codex":[0.9988198,0.00004834869,0.0003516457,0.0004047864,0.0001706514,0.0002048056],"domain_scores_gemma":[0.9993963,0.00003348202,0.00021253,0.0002363954,0.00006923937,0.00005202415],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006584811,0.0002629131,0.005379257,0.00009209704,0.00005174966,0.000002123869,0.001343046,8.829309e-7,0.9703363,0.000006588399,0.006412786,0.0154538],"study_design_scores_gemma":[0.001061963,0.0001552191,0.01655144,0.0004546203,0.00003857015,0.0000356292,0.0001482117,0.00000399871,0.9780098,0.000008217405,0.003397474,0.0001348254],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9841932,0.000198822,0.000001700157,0.01483447,0.0000843204,0.0004709742,0.00003678878,0.00001177534,0.0001679576],"genre_scores_gemma":[0.9917513,0.00320423,0.0002510645,0.004339212,0.0002292107,0.000001186357,0.000008723003,0.00002031197,0.0001947561],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01531897,"threshold_uncertainty_score":0.5329483,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01083303445996736,"score_gpt":0.251220997140693,"score_spread":0.2403879626807256,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}