{"id":"W2141162694","doi":"10.1128/aac.49.4.1529-1541.2005","title":"Expression of<i>ccaR</i>, Encoding the Positive Activator of Cephamycin C and Clavulanic Acid Production in<i>Streptomyces clavuligerus</i>, Is Dependent on<i>bldG</i>","year":2005,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Directorate for Biological Sciences; Fondation pour la Recherche Médicale; University of Alberta","keywords":"Streptomyces clavuligerus; Streptomyces coelicolor; Open reading frame; Biology; Streptomyces; Gene; Regulator gene; Biochemistry; Genetics; Regulation of gene expression; Mutant; Peptide sequence; Actinomycetales; Bacteria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007200061,0.0005971028,0.0002729321,0.0003337433,0.000148989,0.0003086681,0.0001588069,0.0002010254,0.0006013847],"category_scores_gemma":[0.0001547557,0.0001885983,0.0003393163,0.0002565425,0.0002383896,0.0001382891,0.0002443677,0.00042978,0.0006470794],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006493141,"about_ca_system_score_gemma":0.0003796685,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002267265,"about_ca_topic_score_gemma":0.002896508,"domain_scores_codex":[0.9998616,0.00001312857,0.00001254066,0.00003584302,0.0000407107,0.00003612938],"domain_scores_gemma":[0.9997805,0.00003258848,0.00006806565,0.00002511759,0.00002461052,0.00006924813],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002226698,0.000005197072,0.00009889015,0.000009450777,7.162612e-7,0.00002017668,0.00000596949,0.00002278907,0.9993542,0.00002834221,0.00001196518,0.0004200199],"study_design_scores_gemma":[0.000004827402,0.00005563562,0.005827144,0.000004998861,0.000005363655,0.0001468488,0.00002071581,0.0006112835,0.99168,0.00002668515,0.001611236,0.00000530462],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890984,0.0008497199,0.006508085,0.00009010927,0.00002921572,0.00004579634,0.001286741,0.0003216595,0.001770323],"genre_scores_gemma":[0.9867928,0.0003059208,0.005722087,0.00004690656,0.000009346511,0.00003707569,0.003765951,0.0001063795,0.003213539],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002267265,"threshold_uncertainty_score":0.004711151,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01083303445996736,"score_gpt":0.251220997140693,"score_spread":0.2403879626807256,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}