{"id":"W2141191154","doi":"10.1002/anie.201304686","title":"Highly Functionalized Terpyridines as Competitive Inhibitors of AKAP–PKA Interactions","year":2013,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Ministero dello Sviluppo Economico; Ontario Ministry of Economic Development and Innovation; Canadian Institutes of Health Research; Genome Canada; Wellcome Trust; GlaxoSmithKline; Pfizer; Deutsche Forschungsgemeinschaft; Eli Lilly and Company","keywords":"Protein kinase A; Chemistry; Kinase; Computational biology; Cell biology; Biochemistry; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002481719,0.0005144461,0.0003929489,0.0001472274,0.0001681461,0.000240145,0.0004782724,0.0005453881,0.004427683],"category_scores_gemma":[0.0002537622,0.0002735114,0.0002359944,0.0001672633,0.0001951975,0.0005831306,0.000253486,0.001057175,0.00130112],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002350789,"about_ca_system_score_gemma":0.0001402197,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002420039,"about_ca_topic_score_gemma":0.0005224115,"domain_scores_codex":[0.9998382,0.00003393447,0.00001057989,0.00003839043,0.00003784216,0.00004102669],"domain_scores_gemma":[0.999913,0.00002718909,0.00002147084,0.000009539828,0.00001092436,0.00001785592],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008534901,0.00015044,0.00003905139,0.0005534826,0.00003428738,0.0003325337,0.00008092793,0.001325718,0.9748182,0.003658321,0.002124572,0.01602897],"study_design_scores_gemma":[0.0004439106,0.003570008,0.0003927638,0.00004529844,0.00004225977,0.0005386677,0.00003094941,0.003077613,0.9604545,0.0007833339,0.03056516,0.00005554974],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8343276,0.05537758,0.05288176,0.002090259,0.002001519,0.0005517432,0.002010058,0.001335258,0.04942416],"genre_scores_gemma":[0.952008,0.01913756,0.01300712,0.000711763,0.0001719998,0.0002080416,0.0006183969,0.00008728569,0.01404989],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004427683,"threshold_uncertainty_score":0.01481205,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00844465395105211,"score_gpt":0.2486493455479563,"score_spread":0.2402046915969042,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}