{"id":"W2141195374","doi":"10.1371/journal.pgen.1005389","title":"KLK5 Inactivation Reverses Cutaneous Hallmarks of Netherton Syndrome","year":2015,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Skin and Cellular Biology Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":94,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute","funders":"Queensland University of Technology; Institut National de la Santé et de la Recherche Médicale; University of Patras","keywords":"Kallikrein; Proteases; Biology; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001319673,0.0001144763,0.0001482358,0.00004523565,0.00002700005,0.000007726975,0.0002090756,0.0002102585,0.00002922485],"category_scores_gemma":[0.0001622729,0.0001082785,0.00005319575,0.00008847206,0.0001190504,0.000001529838,0.00011983,0.00008842061,0.00001884786],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001626346,"about_ca_system_score_gemma":0.0001169429,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007732971,"about_ca_topic_score_gemma":0.000007938941,"domain_scores_codex":[0.9990897,0.00009621448,0.0001833519,0.0002355454,0.0001896426,0.0002055035],"domain_scores_gemma":[0.9992633,0.00001528649,0.00007702294,0.0003541035,0.0001866077,0.0001036511],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001201574,0.0001300491,0.005960376,0.00002422862,0.0000852887,0.00003921994,0.00005480607,0.00006907911,0.9913595,0.0000226841,0.001191012,0.0009435819],"study_design_scores_gemma":[0.0003777895,0.0008821792,0.0002264009,0.00001527704,0.00002188777,0.000354695,0.0001323305,0.0003257165,0.9879413,0.0001498587,0.009422224,0.0001503486],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994617,0.001610965,0.0001537033,0.00006196174,0.00009590964,0.0001590244,0.000009823373,0.000008570613,0.003283016],"genre_scores_gemma":[0.9978488,0.0003309443,0.0005872654,0.00005141725,0.00008854001,0.000009415279,0.0001114252,0.00002124315,0.0009509588],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008231211,"threshold_uncertainty_score":0.4415467,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03443727382652702,"score_gpt":0.2711875149843689,"score_spread":0.2367502411578419,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}