{"id":"W2141195374","doi":"10.1371/journal.pgen.1005389","title":"KLK5 Inactivation Reverses Cutaneous Hallmarks of Netherton Syndrome","year":2015,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Skin and Cellular Biology Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":94,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute","funders":"Queensland University of Technology; Institut National de la Santé et de la Recherche Médicale; University of Patras","keywords":"Kallikrein; Proteases; Biology; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009636101,0.0004594715,0.0001985235,0.0004332276,0.0001069517,0.0002232914,0.0002619147,0.0003788387,0.001606718],"category_scores_gemma":[0.0001377613,0.0001661538,0.000233989,0.0001140264,0.00024851,0.000188305,0.0001763838,0.0005323302,0.000326504],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002031407,"about_ca_system_score_gemma":0.0001509216,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004934808,"about_ca_topic_score_gemma":0.001006623,"domain_scores_codex":[0.9998263,0.00001742633,0.00002938202,0.00004178254,0.00005500268,0.00003020358],"domain_scores_gemma":[0.999821,0.00002114842,0.00006478246,0.00001756246,0.00001416779,0.00006131368],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001023275,0.0000366196,0.0003109906,0.00005764435,0.00001281101,0.0004051097,0.00001190733,0.00006039918,0.9965895,0.0001462354,0.00007404356,0.002192428],"study_design_scores_gemma":[0.00007224155,0.0009455813,0.01563458,0.00002448691,0.00007916707,0.004297375,0.00006201646,0.001078109,0.9708583,0.0001395362,0.006795089,0.00001361558],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922509,0.001480657,0.003165921,0.0001160584,0.00008643429,0.00004243482,0.0006020053,0.000291031,0.001964518],"genre_scores_gemma":[0.9922673,0.001041579,0.001797368,0.0001015774,0.00001680777,0.00002980969,0.0007092229,0.00004667983,0.003989564],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001606718,"threshold_uncertainty_score":0.005374968,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03443727382652702,"score_gpt":0.2711875149843689,"score_spread":0.2367502411578419,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}