{"id":"W2141208964","doi":"10.1038/mt.2011.190","title":"Influence of Cationic Lipid Composition on Gene Silencing Properties of Lipid Nanoparticle Formulations of siRNA in Antigen-Presenting Cells","year":2011,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":178,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Drug Research and Development; Encana (Canada); University of British Columbia","funders":"Canadian Institutes of Health Research; Alnylam Pharmaceuticals","keywords":"Gene silencing; Cationic polymerization; Nanoparticle; Chemistry; Antigen; Solid lipid nanoparticle; Composition (language); RNA interference; Gene; Cell biology; Biophysics; Biochemistry; Biology; Materials science; Nanotechnology; RNA; Immunology; Polymer chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001050924,0.00008796755,0.000136108,0.0000712484,0.0000218026,0.00000300571,0.0001454903,0.00005953969,0.00000509317],"category_scores_gemma":[0.00001139441,0.00008230206,0.00006617969,0.0001081526,0.0000601575,0.000009270315,0.00003172291,0.000037115,0.000001539262],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006296412,"about_ca_system_score_gemma":0.00003703317,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001396078,"about_ca_topic_score_gemma":0.000008330853,"domain_scores_codex":[0.999248,0.00005922076,0.0003139154,0.0001527891,0.0001058371,0.0001202105],"domain_scores_gemma":[0.9994059,0.000004515795,0.0001650709,0.0002552106,0.0001498122,0.00001944469],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001358169,0.0001716034,0.004728094,0.00002035518,0.00003136697,6.648339e-7,0.000666679,0.005333855,0.9885757,0.00005961995,0.000001345866,0.0002749277],"study_design_scores_gemma":[0.000333074,0.0003626867,0.01324788,0.00006709365,0.000003978225,9.162187e-7,0.00003706049,0.0002126073,0.9856049,0.00004520412,0.000005134721,0.00007950243],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990261,0.0003474235,0.0003104008,0.000006728809,0.00002566197,0.0001656328,0.000004704245,0.000002966377,0.0001104494],"genre_scores_gemma":[0.9993315,0.0002613892,0.000315189,0.00004305693,0.00001326697,0.000009749152,0.000008780212,0.00001030386,0.000006738157],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008519789,"threshold_uncertainty_score":0.3356181,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02468615966362248,"score_gpt":0.2368702135300832,"score_spread":0.2121840538664607,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}