{"id":"W2141208964","doi":"10.1038/mt.2011.190","title":"Influence of Cationic Lipid Composition on Gene Silencing Properties of Lipid Nanoparticle Formulations of siRNA in Antigen-Presenting Cells","year":2011,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":178,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Drug Research and Development; Encana (Canada); University of British Columbia","funders":"Canadian Institutes of Health Research; Alnylam Pharmaceuticals","keywords":"Gene silencing; Cationic polymerization; Nanoparticle; Chemistry; Antigen; Solid lipid nanoparticle; Composition (language); RNA interference; Gene; Cell biology; Biophysics; Biochemistry; Biology; Materials science; Nanotechnology; RNA; Immunology; Polymer chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003723161,0.0002903067,0.0002096377,0.0001439438,0.0001175652,0.0004639611,0.0001428013,0.0002147714,0.0005503676],"category_scores_gemma":[0.0005295448,0.0001491664,0.0001328455,0.0001569924,0.0001952958,0.0002655347,0.0001490805,0.0002581092,0.0002430444],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000348025,"about_ca_system_score_gemma":0.0002438224,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009745456,"about_ca_topic_score_gemma":0.0007773616,"domain_scores_codex":[0.9998066,0.00005178707,0.0000264505,0.00004124658,0.0000422322,0.00003172247],"domain_scores_gemma":[0.999774,0.0000903285,0.00005068917,0.000009827801,0.00004777099,0.00002740883],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001176397,0.00001367807,0.00008559422,0.00002683834,0.000004337958,0.00002265107,0.00002415489,0.0001379366,0.998915,0.00002835051,0.00001070927,0.0006132019],"study_design_scores_gemma":[0.000009482791,0.0001601036,0.0003708302,0.000002100218,0.00001098159,0.00001937547,0.00001041846,0.0005210572,0.9985597,0.000006745719,0.0003260456,0.000003175168],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970951,0.0005632123,0.001277506,0.0000370551,0.00001387846,0.00002900456,0.00009795752,0.00002142816,0.0008648965],"genre_scores_gemma":[0.9971923,0.00046009,0.00140748,0.00003487369,0.000004833107,0.00003277576,0.0001168526,0.00002229697,0.0007285],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009745456,"threshold_uncertainty_score":0.002525151,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02468615966362248,"score_gpt":0.2368702135300832,"score_spread":0.2121840538664607,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}