{"id":"W2141216786","doi":"10.1128/iai.00382-12","title":"The Pseudomonas aeruginosa PhoP-PhoQ Two-Component Regulatory System Is Induced upon Interaction with Epithelial Cells and Controls Cytotoxicity and Inflammation","year":2012,"lang":"en","type":"article","venue":"Infection and Immunity","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research","keywords":"Pseudomonas aeruginosa; Biology; Virulence; Microbiology; Mutant; Operon; Lipopolysaccharide; Lipid A; Mutation; Phenotype; Wild type; Bacteria; Gene; Immunology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004029522,0.0001400027,0.0001276676,0.00002975662,0.0003637456,0.00008550988,0.00003608256,0.0001063372,0.000002435936],"category_scores_gemma":[0.00002409175,0.0001014244,0.0000241203,0.00003732262,0.0001068594,0.000035211,0.0000605125,0.0001421137,0.000002046712],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003481177,"about_ca_system_score_gemma":0.00001648409,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000283044,"about_ca_topic_score_gemma":0.00009895639,"domain_scores_codex":[0.9992225,0.0002048148,0.0001834155,0.0001495367,0.00007951439,0.0001602581],"domain_scores_gemma":[0.9994513,0.0000394375,0.0001598915,0.0002146518,0.00006569234,0.00006896265],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003283931,0.00002214527,0.02331584,0.00003360158,0.00004685156,1.917972e-7,0.0001476141,0.000001524676,0.9739541,0.0001059347,0.00001680292,0.002026931],"study_design_scores_gemma":[0.0008055538,0.0001535849,0.2553819,0.00003823863,0.00002685001,0.00007188514,0.0002722734,0.0001225537,0.7408053,0.000005840018,0.002185665,0.0001303914],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985557,0.0001933984,0.000450364,0.00004108808,0.0002625342,0.0002757095,0.000006947677,0.00001812604,0.0001961825],"genre_scores_gemma":[0.9993647,0.0003274527,0.00003634342,0.00003209909,0.0001770212,0.000009979368,0.00001261247,0.00001077685,0.00002903125],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2331489,"threshold_uncertainty_score":0.4135966,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008411511710266405,"score_gpt":0.2353696247769361,"score_spread":0.2269581130666697,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}