{"id":"W2141272738","doi":"10.1158/1078-0432.ccr-07-5234","title":"Extended Efficacy and Safety of Denosumab in Breast Cancer Patients with Bone Metastases Not Receiving Prior Bisphosphonate Therapy","year":2008,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Bone health and treatments","field":"Medicine","cited_by":161,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Cancer Foundation","funders":"","keywords":"Denosumab; Medicine; Breast cancer; Internal medicine; Urology; Bisphosphonate; Adverse effect; Bone resorption; Creatinine; Zoledronic acid; Oncology; Gastroenterology; Cancer; Osteoporosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009202961,0.0002323086,0.001032036,0.0001620886,0.0001626533,0.000315381,0.0001948622,0.0002727372,0.0008888829],"category_scores_gemma":[0.001432434,0.0001249511,0.0005052056,0.0002216671,0.0002152601,0.0001876712,0.0001725921,0.0005125109,0.000166484],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002776223,"about_ca_system_score_gemma":0.0004870879,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004865948,"about_ca_topic_score_gemma":0.001090082,"domain_scores_codex":[0.9995184,0.0002402013,0.00003936698,0.00004725426,0.00009391395,0.0000609701],"domain_scores_gemma":[0.9992773,0.0002304587,0.0002687335,0.00003907497,0.00003736205,0.0001470524],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.460348,0.01236509,0.1471931,0.001023254,0.00216393,0.0004445859,0.0002893154,0.002111658,0.04983189,0.0001318956,0.001202499,0.3228948],"study_design_scores_gemma":[0.1301098,0.4135219,0.4306159,0.0002043403,0.002252623,0.001761325,0.0001733926,0.002635558,0.01269119,0.0002754231,0.005726585,0.00003198033],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961182,0.003152417,0.0001011621,0.00006759789,0.00001386269,0.00006811591,0.00006249935,0.000006860928,0.00040931],"genre_scores_gemma":[0.9986792,0.0007511618,0.0001450898,0.00008723469,0.0000339647,0.0000476253,0.0001394405,9.987124e-7,0.0001152426],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001032036,"threshold_uncertainty_score":0.004867077,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.144216444746257,"score_gpt":0.4772672333406095,"score_spread":0.3330507885943526,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}