{"id":"W2141293359","doi":"10.1158/1535-7163.mct-07-0471","title":"WTp53 induction does not override MTp53 chemoresistance and radioresistance due to gain-of-function in lung cancer cells","year":2008,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"","keywords":"Biology; DNA damage; Cell cycle; Radioresistance; Apoptosis; Cancer research; DNA repair; Molecular biology; Transfection; Cancer cell; Programmed cell death; Cancer; Cell cycle checkpoint; Tumor suppressor gene; Carcinogenesis; Cell culture; DNA; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001048037,0.0002848934,0.0003247376,0.0002112463,0.0001440909,0.0003295584,0.0002395614,0.0002888567,0.001633757],"category_scores_gemma":[0.0001473848,0.0001579844,0.0002634512,0.0002108555,0.0002242517,0.0002213617,0.0002310105,0.000649701,0.0006338781],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002889492,"about_ca_system_score_gemma":0.0002173881,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000528811,"about_ca_topic_score_gemma":0.0007251668,"domain_scores_codex":[0.9998185,0.0000218257,0.00002230918,0.00004065486,0.00006454511,0.0000322116],"domain_scores_gemma":[0.999828,0.00002788187,0.00004629177,0.00004904067,0.00001751511,0.00003135276],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004448808,0.00002106615,0.0001809353,0.00001306124,0.000002600118,0.00004928869,0.000005507921,0.00004205268,0.9988508,0.00006546987,0.00002370339,0.0007008917],"study_design_scores_gemma":[0.00001216842,0.0002379115,0.003326143,0.000002740233,0.000007513371,0.0004726251,0.00001552936,0.0005956367,0.9938762,0.00004053533,0.001410737,0.000002323163],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954047,0.00095336,0.001899701,0.00009404988,0.00001920837,0.00002973227,0.0003778813,0.0001244186,0.001096891],"genre_scores_gemma":[0.996845,0.0003236502,0.0008587953,0.00002871655,0.000006040553,0.00002564698,0.000551686,0.00002522121,0.001335374],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001633757,"threshold_uncertainty_score":0.005465508,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01783123944710964,"score_gpt":0.267577180471563,"score_spread":0.2497459410244534,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}