{"id":"W2141319262","doi":"10.1086/496899","title":"A Variant in XPNPEP2 Is Associated with Angioedema Induced by Angiotensin I–Converting Enzyme Inhibitors","year":2005,"lang":"en","type":"article","venue":"The American Journal of Human Genetics","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":127,"is_retracted":false,"has_abstract":false,"ca_institutions":"Cegep de Saint Jerome; Montreal Heart Institute; McGill University; Université de Montréal; Hôpital Notre-Dame","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; National Institutes of Health; McGill University","keywords":"Angioedema; Angiotensin-converting enzyme; Enzyme; Renin–angiotensin system; Medicine; Pharmacology; Chemistry; Internal medicine; Biochemistry; Blood pressure","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00061027,0.002356583,0.0007907456,0.001535816,0.001164909,0.0007444136,0.0009483904,0.002993545,0.004721084],"category_scores_gemma":[0.003370999,0.0003483994,0.001071302,0.0009757018,0.001081873,0.0006727175,0.0005454661,0.001865344,0.0007599352],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003089298,"about_ca_system_score_gemma":0.0002794189,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001295798,"about_ca_topic_score_gemma":0.0008457425,"domain_scores_codex":[0.9993024,0.0001905303,0.00009897834,0.0001441847,0.0001507761,0.0001130461],"domain_scores_gemma":[0.9974819,0.001366493,0.0004098718,0.000107937,0.0001757053,0.000458038],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"observational","study_design_scores_codex":[0.001721212,0.0005957551,0.04756952,0.0001094607,0.0002771709,0.9063335,0.0004992162,0.0003460789,0.03502366,0.001314742,0.001799705,0.00441003],"study_design_scores_gemma":[0.0004680999,0.001039402,0.1806899,0.00009739116,0.0003082124,0.801994,0.0003491697,0.002592824,0.007721362,0.001176809,0.003474303,0.00008854147],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899677,0.0005549278,0.002066886,0.001541235,0.0004155312,0.0001183675,0.0004157284,0.00008870525,0.004830847],"genre_scores_gemma":[0.99689,0.0001275246,0.0006301895,0.0003356395,0.0004188226,0.00001958437,0.0001533228,0.0000223102,0.001402654],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004721084,"threshold_uncertainty_score":0.01579356,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01687343724071374,"score_gpt":0.2656343671704085,"score_spread":0.2487609299296948,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}