{"id":"W2141321721","doi":"10.1091/mbc.e07-05-0491","title":"Disulfide Bond-mediated Multimerization of Ask1 and Its Reduction by Thioredoxin-1 Regulate H<sub>2</sub>O<sub>2</sub>-induced c-Jun NH<sub>2</sub>-terminal Kinase Activation and Apoptosis","year":2007,"lang":"en","type":"article","venue":"Molecular Biology of the Cell","topic":"Redox biology and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":175,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Hôtel-Dieu de Québec","funders":"Canadian Institutes of Health Research","keywords":"ASK1; Thioredoxin; Kinase; Cell biology; Signal transduction; Biology; Protein kinase A; Biochemistry; Enzyme; Mitogen-activated protein kinase kinase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000198396,0.0004218983,0.0002359891,0.0001559187,0.0001709112,0.0003277314,0.0002465502,0.0003570334,0.001135771],"category_scores_gemma":[0.0001090335,0.000173211,0.0003035406,0.0001349646,0.000260271,0.0003896484,0.0002435092,0.0005014507,0.0003229768],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003262678,"about_ca_system_score_gemma":0.0001548522,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002261754,"about_ca_topic_score_gemma":0.0003072105,"domain_scores_codex":[0.9998821,0.00002039287,0.00001214472,0.00002818936,0.00002488523,0.00003224445],"domain_scores_gemma":[0.9999242,0.000005641169,0.00003576673,0.000006117506,0.000009622959,0.00001859301],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001844679,0.00005290826,0.0001823568,0.00003288114,0.000009272208,0.00003614826,0.00002814493,0.00007534331,0.9983016,0.0001872815,0.0000498767,0.0008597025],"study_design_scores_gemma":[0.00002085863,0.00015757,0.003693666,0.00000237286,0.00001044777,0.0001586002,0.00003546978,0.001386201,0.9931074,0.0001121356,0.001310088,0.000005328513],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945074,0.002367982,0.002206536,0.0001163164,0.00004127205,0.00002533727,0.0001134596,0.00004871039,0.0005730768],"genre_scores_gemma":[0.9957401,0.00101583,0.00113234,0.00004877397,0.00001340898,0.00003717219,0.0002436102,0.000008472623,0.001760311],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001135771,"threshold_uncertainty_score":0.003799498,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005027808600682218,"score_gpt":0.2261641020113396,"score_spread":0.2211362934106574,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}