{"id":"W2141321721","doi":"10.1091/mbc.e07-05-0491","title":"Disulfide Bond-mediated Multimerization of Ask1 and Its Reduction by Thioredoxin-1 Regulate H<sub>2</sub>O<sub>2</sub>-induced c-Jun NH<sub>2</sub>-terminal Kinase Activation and Apoptosis","year":2007,"lang":"en","type":"article","venue":"Molecular Biology of the Cell","topic":"Redox biology and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":175,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Hôtel-Dieu de Québec","funders":"Canadian Institutes of Health Research","keywords":"ASK1; Thioredoxin; Kinase; Cell biology; Signal transduction; Biology; Protein kinase A; Biochemistry; Enzyme; Mitogen-activated protein kinase kinase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005460232,0.0004838405,0.0005040257,0.0001774667,0.0002204932,0.00001517248,0.0003168032,0.0009181203,0.000001412911],"category_scores_gemma":[0.0002657984,0.0004186385,0.0001900184,0.0003150489,0.0006757079,0.00002717611,0.0002874742,0.0003248453,0.000003159],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003417573,"about_ca_system_score_gemma":0.00007518417,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001508485,"about_ca_topic_score_gemma":0.000008900685,"domain_scores_codex":[0.9972829,0.0004407256,0.0006890877,0.0008763649,0.0001837279,0.0005272413],"domain_scores_gemma":[0.998182,0.00007716638,0.0007668799,0.0005538354,0.0002632175,0.0001568925],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005688351,0.0001717032,0.000848881,0.00008583719,0.0001593908,0.000003027279,0.0001019339,0.00001767814,0.9912667,0.00002691092,0.0001132709,0.006635785],"study_design_scores_gemma":[0.001311576,0.000594256,0.005861964,0.00006747162,0.000127268,0.0000308851,0.0001012936,0.0000762532,0.9912062,0.0001334937,0.00006899573,0.0004204032],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953524,0.001098614,0.00221721,0.0001955043,0.0002917728,0.0006577718,0.0001092725,0.00002409123,0.00005330328],"genre_scores_gemma":[0.9976476,0.0009724263,0.0001528979,0.0001286103,0.00009425647,0.00002778497,0.0009115887,0.00005172685,0.00001311009],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006215381,"threshold_uncertainty_score":0.9998266,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005027808600682218,"score_gpt":0.2261641020113396,"score_spread":0.2211362934106574,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}