{"id":"W2141323228","doi":"10.1158/1535-7163.mct-11-0826","title":"Next Generation Sequencing of Prostate Cancer from a Patient Identifies a Deficiency of Methylthioadenosine Phosphorylase, an Exploitable Tumor Target","year":2012,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"National Cancer Institute; Canadian Institutes of Health Research","keywords":"Prostate cancer; Cancer; Prostate; Cancer research; Medicine; Gene; Chromoplexy; DNA sequencing; Internal medicine; Oncology; Biology; PCA3; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001008691,0.0002219416,0.0002569954,0.0003179038,0.000242313,0.000251571,0.0001221155,0.0004243811,0.001335807],"category_scores_gemma":[0.0002463771,0.0001230869,0.0002563137,0.000193762,0.0001106215,0.00008020953,0.0001171869,0.000336585,0.0002345606],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002124048,"about_ca_system_score_gemma":0.0002058696,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001186519,"about_ca_topic_score_gemma":0.003524772,"domain_scores_codex":[0.9999332,0.000008707929,0.000004642594,0.0000198034,0.00002054101,0.00001310306],"domain_scores_gemma":[0.999917,0.00002818711,0.00001074584,0.000008734377,0.0000120345,0.00002330998],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0005770884,0.00008414081,0.03353075,0.0001086388,0.00009241096,0.008795189,0.0002434013,0.0007911572,0.9306048,0.0004485561,0.001410248,0.02331369],"study_design_scores_gemma":[0.00007360683,0.001166464,0.2312769,0.00003247737,0.0003799367,0.06014062,0.0003517696,0.01124546,0.6629012,0.0009900623,0.03140319,0.00003838355],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9866124,0.0009264604,0.007564478,0.0004083527,0.00003534328,0.00004924635,0.002403523,0.0001829445,0.001817296],"genre_scores_gemma":[0.9840546,0.0006124429,0.01099996,0.0002335798,0.00001589636,0.00002673882,0.002475031,0.00004349927,0.001538163],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001335807,"threshold_uncertainty_score":0.004468679,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08997307342824663,"score_gpt":0.333837620100031,"score_spread":0.2438645466717844,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}