{"id":"W2141387887","doi":"10.1534/genetics.108.092577","title":"A Genomewide Suppressor and Enhancer Analysis of <i>cdc13-1</i> Reveals Varied Cellular Processes Influencing Telomere Capping in <i>Saccharomyces cerevisiae</i>","year":2008,"lang":"en","type":"article","venue":"Genetics","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":85,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto","funders":"Biotechnology and Biological Sciences Research Council; Wellcome Trust","keywords":"Telomere; Biology; Saccharomyces cerevisiae; Gene; Telomerase; Mutant; Genetics; Mutation; Telomere-binding protein; Cell biology; DNA damage; DNA; Cell cycle; DNA-binding protein","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002215803,0.0002885427,0.0005346266,0.0002400507,0.0001081085,0.00002729165,0.0003043685,0.0002145992,0.00002156554],"category_scores_gemma":[0.00009198953,0.0003067304,0.0001063403,0.0006714131,0.000193794,0.000008265229,0.0002077792,0.0001281174,0.000001959259],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001772761,"about_ca_system_score_gemma":0.0001628829,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007461548,"about_ca_topic_score_gemma":0.0002285377,"domain_scores_codex":[0.9980894,0.00007939103,0.0005865993,0.0005877948,0.0002435875,0.0004131754],"domain_scores_gemma":[0.9988514,0.0000345262,0.0002471626,0.00052699,0.0002188105,0.0001210862],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001926566,0.00005713498,0.09027388,0.0002626801,0.0002968102,0.000008243392,0.002172824,0.004085927,0.9025912,0.000004848924,0.00006772455,0.0001594888],"study_design_scores_gemma":[0.0004854086,0.000131819,0.02191914,0.00004973255,0.0004247191,0.00001614186,0.0002388553,0.0002465094,0.9744965,0.00006573157,0.001497203,0.0004282776],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9830058,0.01378835,0.002671639,0.00003259982,0.00004798386,0.0002552065,0.00004847724,0.00001208943,0.0001378516],"genre_scores_gemma":[0.9892827,0.00584568,0.004319955,0.000211979,0.00009746591,0.00002064582,0.00007926773,0.00003820296,0.0001041608],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07190529,"threshold_uncertainty_score":0.9999385,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01218977914237294,"score_gpt":0.2241379516707815,"score_spread":0.2119481725284086,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}