{"id":"W2141387887","doi":"10.1534/genetics.108.092577","title":"A Genomewide Suppressor and Enhancer Analysis of <i>cdc13-1</i> Reveals Varied Cellular Processes Influencing Telomere Capping in <i>Saccharomyces cerevisiae</i>","year":2008,"lang":"en","type":"article","venue":"Genetics","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":85,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto","funders":"Biotechnology and Biological Sciences Research Council; Wellcome Trust","keywords":"Telomere; Biology; Saccharomyces cerevisiae; Gene; Telomerase; Mutant; Genetics; Mutation; Telomere-binding protein; Cell biology; DNA damage; DNA; Cell cycle; DNA-binding protein","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001176759,0.0004889309,0.000210461,0.0003837715,0.0001922891,0.000348592,0.0003448042,0.0002164252,0.001048793],"category_scores_gemma":[0.0001448872,0.000180855,0.0002868475,0.0002813583,0.0002933273,0.0000697681,0.0001957699,0.0004889127,0.0004029064],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004037084,"about_ca_system_score_gemma":0.0002946061,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002366099,"about_ca_topic_score_gemma":0.004720566,"domain_scores_codex":[0.9998965,0.00001043335,0.00001091285,0.00003012731,0.00003272026,0.00001915918],"domain_scores_gemma":[0.9998085,0.00005151306,0.0000596479,0.00001841919,0.00001616043,0.00004574545],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005446886,0.00001815841,0.000320444,0.00001722545,0.000004080515,0.00006621489,0.000007495945,0.00008204763,0.9984688,0.00007259893,0.00003149486,0.000856946],"study_design_scores_gemma":[0.00001185976,0.00008133864,0.01070818,0.000008023863,0.00002633288,0.0004047231,0.00002440983,0.001531058,0.9853765,0.00005102499,0.001768012,0.00000845853],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910923,0.0005747571,0.005117039,0.00006612291,0.00001893028,0.00004006773,0.001791478,0.0002633211,0.001036043],"genre_scores_gemma":[0.9893987,0.0003882969,0.00444812,0.00007298665,0.000006571393,0.00003143479,0.003191415,0.000129747,0.00233263],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002366099,"threshold_uncertainty_score":0.004704714,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01218977914237294,"score_gpt":0.2241379516707815,"score_spread":0.2119481725284086,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}