{"id":"W2141391452","doi":"10.1124/jpet.106.110387","title":"Prostacyclin Antagonism Reduces Pain and Inflammation in Rodent Models of Hyperalgesia and Chronic Arthritis","year":2006,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":113,"is_retracted":false,"has_abstract":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Arthritis; Medicine; Inflammation; Rheumatoid arthritis; Osteoarthritis; Pharmacology; Receptor antagonist; Hyperalgesia; Diclofenac; Antagonist; Cyclooxygenase; Proinflammatory cytokine; Prostaglandin; Receptor; Internal medicine; Nociception; Chemistry; Pathology; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003693929,0.0008328381,0.001150032,0.000959362,0.0004963332,0.0005817753,0.0005966673,0.0007660902,0.00265443],"category_scores_gemma":[0.0005943451,0.000370812,0.0004181188,0.0004716154,0.0009094944,0.0005780846,0.0002497401,0.002734242,0.0004014248],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004687173,"about_ca_system_score_gemma":0.000943429,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001135831,"about_ca_topic_score_gemma":0.003846766,"domain_scores_codex":[0.9996108,0.00006255457,0.00002626408,0.00003775736,0.0001106159,0.0001520478],"domain_scores_gemma":[0.9994949,0.00005969064,0.0001531095,0.00004268624,0.00003889177,0.0002106966],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01748294,0.003816041,0.0008121505,0.0004578544,0.0001237549,0.0002975496,0.00009818792,0.0007543939,0.9502934,0.0008035829,0.0007223395,0.02433786],"study_design_scores_gemma":[0.004270046,0.04774764,0.02256376,0.0001570799,0.0004167659,0.00105192,0.0003076722,0.002552651,0.9149741,0.0008149887,0.005064846,0.0000784783],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912474,0.004722011,0.001001915,0.000524122,0.0001924875,0.00007853909,0.0003479192,0.0001225258,0.001763126],"genre_scores_gemma":[0.985651,0.005856581,0.001876467,0.0002181236,0.0001791314,0.0001503199,0.0008596167,0.00003279306,0.005175946],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00265443,"threshold_uncertainty_score":0.00887996,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01325056070639121,"score_gpt":0.3002423744284427,"score_spread":0.2869918137220515,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}