{"id":"W2141398769","doi":"10.1210/jcem.85.11.6981","title":"Familial Splenomegaly: Macrophage Hypercatabolism of Lipoproteins Associated with Apolipoprotein E Mutation [Apolipoprotein E (Δ149 Leu)]","year":2000,"lang":"en","type":"article","venue":"The Journal of Clinical Endocrinology & Metabolism","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Apolipoprotein E; Mutation; Macrophage; Apolipoprotein B; Apolipoprotein C2; Chemistry; Medicine; Biochemistry; Lipoprotein; Very low-density lipoprotein; Internal medicine; Cholesterol; Gene; Disease; In vitro","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002300649,0.0005028803,0.001618298,0.0001958579,0.0001977974,0.00002596795,0.001105245,0.0004821683,0.0003124848],"category_scores_gemma":[0.001262922,0.0003411585,0.0006811251,0.0003705599,0.001088953,0.00004469241,0.0001432351,0.001158749,0.00002715712],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002450385,"about_ca_system_score_gemma":0.0006200292,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007066004,"about_ca_topic_score_gemma":0.0003628868,"domain_scores_codex":[0.9941965,0.001380776,0.002396117,0.0004869816,0.0006936217,0.0008460026],"domain_scores_gemma":[0.9960881,0.0002335835,0.001742473,0.0009559343,0.0006587863,0.0003210951],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.01899841,0.002766192,0.001714903,0.0001128879,0.004301033,0.00004656996,0.001339055,0.002014664,0.3044292,0.002127972,0.01499294,0.6471561],"study_design_scores_gemma":[0.0166865,0.002919416,0.1006317,0.0001554225,0.001772537,0.001253779,0.0004192209,0.00005054913,0.09153831,0.001399482,0.7822247,0.0009483403],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9817088,0.01177598,0.0003485894,0.0007671206,0.003858147,0.0006491917,0.00009978806,0.00002318334,0.0007691921],"genre_scores_gemma":[0.9607365,0.01281729,0.001077459,0.0009833424,0.02222939,0.00003452848,0.00004780281,0.00009517414,0.001978481],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7672318,"threshold_uncertainty_score":0.999904,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02079712107135092,"score_gpt":0.3026633595888268,"score_spread":0.2818662385174759,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}