{"id":"W2141398769","doi":"10.1210/jcem.85.11.6981","title":"Familial Splenomegaly: Macrophage Hypercatabolism of Lipoproteins Associated with Apolipoprotein E Mutation [Apolipoprotein E (Δ149 Leu)]","year":2000,"lang":"en","type":"article","venue":"The Journal of Clinical Endocrinology & Metabolism","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Apolipoprotein E; Mutation; Macrophage; Apolipoprotein B; Apolipoprotein C2; Chemistry; Medicine; Biochemistry; Lipoprotein; Very low-density lipoprotein; Internal medicine; Cholesterol; Gene; Disease; In vitro","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001640279,0.0009285574,0.00024348,0.0005249993,0.0005493509,0.0002068891,0.0002174546,0.0005366376,0.001330481],"category_scores_gemma":[0.0006765433,0.0002619579,0.0002650079,0.0003326344,0.000745847,0.0001425978,0.0004118143,0.0003817255,0.0001732631],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002184884,"about_ca_system_score_gemma":0.0002272179,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002020407,"about_ca_topic_score_gemma":0.002120094,"domain_scores_codex":[0.999887,0.00002141239,0.00001441356,0.00003113566,0.00002168263,0.00002429734],"domain_scores_gemma":[0.9996157,0.0001198084,0.00010644,0.00002625074,0.00002577319,0.0001061379],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"observational","study_design_scores_codex":[0.0006950774,0.0001130423,0.1919238,0.0001437551,0.0001132821,0.6861888,0.001713434,0.0002899014,0.1103321,0.0004095959,0.0007073612,0.007370022],"study_design_scores_gemma":[0.00008635167,0.0003523476,0.1920443,0.00002393173,0.00009369953,0.7942386,0.000359633,0.0004706701,0.01072063,0.0002075499,0.001371016,0.00003121333],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983546,0.0002106787,0.0006203951,0.00008466114,0.00001119977,0.00000886335,0.00005472357,0.0000316409,0.0006231853],"genre_scores_gemma":[0.999433,0.00007892664,0.0002142281,0.00003411296,0.00001301168,0.000002011603,0.00002714868,0.000005334734,0.0001923188],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002020407,"threshold_uncertainty_score":0.004450977,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02079712107135092,"score_gpt":0.3026633595888268,"score_spread":0.2818662385174759,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}