{"id":"W2141410122","doi":"10.1158/1078-0432.ccr-07-0674","title":"Genetically Targeted T Cells Eradicate Systemic Acute Lymphoblastic Leukemia Xenografts","year":2007,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":466,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Cancer Institute","keywords":"Chimeric antigen receptor; Immunology; Adoptive cell transfer; Cancer research; T cell; Homing (biology); Medicine; Ex vivo; Systemic administration; CD28; Immunotherapy; Leukemia; In vivo; Biology; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.01182176,0.0003477754,0.0009728475,0.0006329559,0.0002935792,0.0001070407,0.000848869,0.0006184974,0.007633899],"category_scores_gemma":[0.001101835,0.0002931771,0.0004673704,0.00177066,0.001643009,0.00007517867,0.0004421939,0.002738963,0.00165706],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002058638,"about_ca_system_score_gemma":0.003537073,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004197487,"about_ca_topic_score_gemma":0.0001091606,"domain_scores_codex":[0.9911961,0.0008524598,0.001573085,0.001216313,0.002904716,0.002257342],"domain_scores_gemma":[0.9919121,0.003335268,0.000137338,0.00138642,0.001338551,0.001890336],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01101208,0.0006246184,0.02477793,0.000497378,0.001019823,0.002137868,0.0002098579,0.00003249083,0.8142546,0.0001365388,0.03509162,0.1102052],"study_design_scores_gemma":[0.03181124,0.0116791,0.1960239,0.002382375,0.0008267016,0.0009118053,0.0005273339,0.004486745,0.3772839,0.0007110121,0.3713591,0.001996801],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9845899,0.003192235,0.0006132639,0.00129638,0.001121613,0.001945578,0.00004053016,0.0001784249,0.007022093],"genre_scores_gemma":[0.9621128,0.007220078,0.0006776449,0.000808335,0.003151006,0.0001939287,0.0000310269,0.0001602522,0.02564496],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4369707,"threshold_uncertainty_score":0.999952,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1267420617162681,"score_gpt":0.4841363589671988,"score_spread":0.3573942972509307,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}