{"id":"W2141410122","doi":"10.1158/1078-0432.ccr-07-0674","title":"Genetically Targeted T Cells Eradicate Systemic Acute Lymphoblastic Leukemia Xenografts","year":2007,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":466,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Cancer Institute","keywords":"Chimeric antigen receptor; Immunology; Adoptive cell transfer; Cancer research; T cell; Homing (biology); Medicine; Ex vivo; Systemic administration; CD28; Immunotherapy; Leukemia; In vivo; Biology; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001151104,0.0004378592,0.0003186265,0.0001717632,0.00008756335,0.0002336307,0.0001545084,0.0001957822,0.0008215331],"category_scores_gemma":[0.0001075782,0.0000828088,0.0001676964,0.00009812458,0.0001667709,0.000136023,0.0001174669,0.000588138,0.0003162584],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002117636,"about_ca_system_score_gemma":0.0002447907,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003743503,"about_ca_topic_score_gemma":0.0006079035,"domain_scores_codex":[0.9998746,0.00001508122,0.000008949701,0.00002585087,0.000039994,0.00003544489],"domain_scores_gemma":[0.9999207,0.00001259238,0.00002859719,0.00001211497,0.000007300879,0.00001873145],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001213133,0.0001140835,0.0003105089,0.00003399427,0.000006670906,0.00003843739,0.00001206198,0.0003158484,0.9946522,0.00008313387,0.00007679385,0.004235054],"study_design_scores_gemma":[0.0001096231,0.001303226,0.001912313,0.000006620427,0.00003735827,0.0003946045,0.00001174408,0.001592919,0.9917,0.00003396089,0.002895261,0.000002316443],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933211,0.0009434708,0.004153584,0.00007915941,0.00001931301,0.00008026687,0.0001411158,0.0002019347,0.001060075],"genre_scores_gemma":[0.9946547,0.0006259638,0.002546669,0.00003272002,0.00002080964,0.00004856656,0.0002748739,0.00003536337,0.001760279],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008215331,"threshold_uncertainty_score":0.002748311,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1267420617162681,"score_gpt":0.4841363589671988,"score_spread":0.3573942972509307,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}