{"id":"W2141440190","doi":"10.1073/pnas.0812938106","title":"Enzymological and structural studies of the mechanism of promiscuous substrate recognition by the oxidative DNA repair enzyme AlkB","year":2009,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":91,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; National Institutes of Health; Terry Fox Foundation; American Heart Association","keywords":"AlkB; Chemistry; DNA; Stereochemistry; Enzyme; Active site; Substrate (aquarium); Biochemistry; Purine; DNA repair; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002115682,0.0004977133,0.0004486033,0.0001945329,0.0003447868,0.0004373934,0.0005914443,0.0005389549,0.0006066562],"category_scores_gemma":[0.0003459979,0.00033577,0.0003420395,0.0004183292,0.0003025768,0.0003996494,0.0002200778,0.001019229,0.0003197506],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008323194,"about_ca_system_score_gemma":0.0004047714,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00214413,"about_ca_topic_score_gemma":0.001682117,"domain_scores_codex":[0.9998651,0.0000204938,0.000008254849,0.00002754242,0.00005860154,0.00002001718],"domain_scores_gemma":[0.9998626,0.00003107346,0.00003925552,0.0000145584,0.00002286189,0.00002967905],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002304886,0.0001649215,0.00311432,0.0002715392,0.00004957992,0.0002467063,0.0001709654,0.005470198,0.9827591,0.001488178,0.0002594339,0.0057747],"study_design_scores_gemma":[0.00006367394,0.00025081,0.01021132,0.00001894195,0.00004195623,0.0008733103,0.0001851764,0.0244043,0.9576879,0.0006181634,0.005601929,0.00004240637],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907653,0.003705562,0.004155548,0.0001994052,0.0000105503,0.00001344271,0.0002603683,0.00004210406,0.0008476371],"genre_scores_gemma":[0.988951,0.003049105,0.005869216,0.00005433597,0.000007801917,0.00002249247,0.00134056,0.00002259998,0.000682777],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00214413,"threshold_uncertainty_score":0.006038904,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04120522147956539,"score_gpt":0.3011829574801892,"score_spread":0.2599777360006238,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}