{"id":"W2141447309","doi":"10.1517/14728222.4.4.541","title":"The insulin receptor kinase: modulation and therapeutic implications","year":2000,"lang":"en","type":"article","venue":"Emerging Therapeutic Targets","topic":"Vanadium and Halogenation Chemistry","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; McGill University","funders":"","keywords":"Autophosphorylation; Insulin receptor; Cell biology; Insulin; Biology; Phosphorylation; Protein kinase A; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001636225,0.000192347,0.000127273,0.00002503413,0.0007093695,0.00008443751,0.0002449556,0.0001135679,0.004388208],"category_scores_gemma":[0.00001524699,0.0001537627,0.00006565455,0.0001371545,0.0001118787,0.00006661451,0.00002109068,0.0001922289,0.00008559474],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005910442,"about_ca_system_score_gemma":0.00003809539,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002080237,"about_ca_topic_score_gemma":0.00001357291,"domain_scores_codex":[0.9988798,0.00002887683,0.0002777779,0.000313688,0.0001713392,0.0003284658],"domain_scores_gemma":[0.999194,0.0001326536,0.00008376916,0.0004315831,0.00006052446,0.00009749652],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004287334,0.00005886483,0.001080122,0.00002616337,0.0001270055,5.951272e-7,0.0007344309,0.000132594,0.2665309,0.002746741,0.0006679305,0.7278518],"study_design_scores_gemma":[0.0007644714,0.00001520489,0.009204824,0.00002375433,0.00005563626,0.00001761887,0.0002493641,0.004592081,0.03430543,0.01216083,0.938152,0.0004588501],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.878776,0.04247274,0.000638193,0.02457261,0.0003358233,0.0003368623,0.00008947319,0.0006552605,0.0521231],"genre_scores_gemma":[0.9917547,0.001510047,0.0001546235,0.0004469485,0.000210765,0.00005907521,0.00005987432,0.00003623951,0.005767761],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.937484,"threshold_uncertainty_score":0.9965219,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01526397074828812,"score_gpt":0.2560361876563313,"score_spread":0.2407722169080432,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}