{"id":"W2141453591","doi":"10.1158/1078-0432.ccr-11-0859","title":"Randomized Phase II Trial of Custirsen (OGX-011) in Combination with Docetaxel or Mitoxantrone as Second-line Therapy in Patients with Metastatic Castrate-Resistant Prostate Cancer Progressing after First-line Docetaxel: CUOG Trial P-06c","year":2011,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Clusterin in disease pathology","field":"Medicine","cited_by":128,"is_retracted":false,"has_abstract":true,"ca_institutions":"CancerCare Manitoba; Queen Elizabeth II Health Sciences Centre; Juravinski Cancer Centre","funders":"","keywords":"Docetaxel; Mitoxantrone; Medicine; Prostate cancer; Internal medicine; Prednisone; Oncology; Cancer; Chemotherapy; Urology; Surgery; Gastroenterology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.005787106,0.0004502049,0.002331097,0.0006164075,0.0001174968,0.00004145148,0.0003040643,0.0002258757,0.002110292],"category_scores_gemma":[0.001822113,0.0002719986,0.0002295158,0.001083023,0.001734394,0.0002401052,0.0001692506,0.001280912,0.000006632541],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003402717,"about_ca_system_score_gemma":0.002440025,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001491011,"about_ca_topic_score_gemma":0.007797775,"domain_scores_codex":[0.9919497,0.00224992,0.002411935,0.000995046,0.001436265,0.0009571051],"domain_scores_gemma":[0.9955172,0.001528924,0.0007363182,0.0007007124,0.001111905,0.0004049386],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9526691,0.01917854,0.01569815,0.0004541842,0.0003785927,0.0006785035,0.001161227,0.00001685407,0.0000380188,0.000006482074,0.00005844946,0.009661867],"study_design_scores_gemma":[0.9182065,0.06345827,0.01541327,0.001258348,0.0002852539,0.000004938594,0.0001129118,0.0003242879,0.0003653067,0.0001391466,0.0001332954,0.0002984958],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9821239,0.001005139,0.00001153334,0.0009605611,0.0003637694,0.01518225,0.0002195509,0.00003091953,0.0001023578],"genre_scores_gemma":[0.9905566,0.0008675926,0.0005321025,0.000123656,0.0002777937,0.006927358,0.00008537269,0.00009606408,0.0005334599],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04427973,"threshold_uncertainty_score":0.9999732,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2142580152465654,"score_gpt":0.5016571026383948,"score_spread":0.2873990873918294,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}