{"id":"W2141510712","doi":"10.1124/jpet.112.202242","title":"Refining the UGT1A Haplotype Associated with Irinotecan-Induced Hematological Toxicity in Metastatic Colorectal Cancer Patients Treated with 5-Fluorouracil/Irinotecan-Based Regimens","year":2013,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Centre hospitalier de l'Université Laval; Hôtel-Dieu de Québec; Ottawa Hospital","funders":"National Cancer Institute; Canadian Institutes of Health Research; Université Laval","keywords":"Irinotecan; Haplotype; Single-nucleotide polymorphism; Internal medicine; Pharmacogenetics; Oncology; Colorectal cancer; SNP; Biology; Medicine; Cancer; Genotype; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001905199,0.0002421461,0.0003270343,0.00006196528,0.0001285442,0.00002978463,0.0001736537,0.0001317398,0.00006998028],"category_scores_gemma":[0.000005448956,0.0001431508,0.00006154769,0.0001369346,0.0001763024,0.00001660835,0.00003849244,0.0003030072,8.339652e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001125044,"about_ca_system_score_gemma":0.000171423,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006204368,"about_ca_topic_score_gemma":0.00009048804,"domain_scores_codex":[0.9987393,0.0002095711,0.0003265216,0.0002177663,0.0001936986,0.0003131492],"domain_scores_gemma":[0.9992285,0.000062865,0.0003607375,0.00008293273,0.0001812984,0.00008364757],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002075111,0.000950311,0.00849513,0.000004995098,0.0005555002,0.00001986709,0.0001874046,0.000166219,0.9863539,0.00001097646,0.00005614146,0.001124406],"study_design_scores_gemma":[0.005215057,0.007533267,0.005623925,0.00003266829,0.0001818086,0.00004668345,0.0002168487,0.0003826419,0.980136,0.00001208209,0.0003978217,0.0002211922],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978532,0.001107873,0.00005065267,0.0005236549,0.000124452,0.0002857682,0.000008487395,0.000007170836,0.00003875153],"genre_scores_gemma":[0.9973077,0.00009593528,0.0001387375,0.002272081,0.00005015966,0.00007084026,0.000009399377,0.00002788303,0.00002728035],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006582956,"threshold_uncertainty_score":0.5837521,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0259598995187916,"score_gpt":0.3057188708231988,"score_spread":0.2797589713044072,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}