{"id":"W2141510712","doi":"10.1124/jpet.112.202242","title":"Refining the UGT1A Haplotype Associated with Irinotecan-Induced Hematological Toxicity in Metastatic Colorectal Cancer Patients Treated with 5-Fluorouracil/Irinotecan-Based Regimens","year":2013,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Centre hospitalier de l'Université Laval; Hôtel-Dieu de Québec; Ottawa Hospital","funders":"National Cancer Institute; Canadian Institutes of Health Research; Université Laval","keywords":"Irinotecan; Haplotype; Single-nucleotide polymorphism; Internal medicine; Pharmacogenetics; Oncology; Colorectal cancer; SNP; Biology; Medicine; Cancer; Genotype; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001869376,0.0002220415,0.000288749,0.0004821706,0.0003442099,0.0003157432,0.0001638705,0.0002876831,0.001545588],"category_scores_gemma":[0.001176287,0.0001342005,0.0002813251,0.0006484573,0.0002002268,0.0001885541,0.00015624,0.0004497532,0.0001376162],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002480337,"about_ca_system_score_gemma":0.0002564222,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001942146,"about_ca_topic_score_gemma":0.002175081,"domain_scores_codex":[0.9997841,0.00007180319,0.00002760074,0.00004300484,0.00003321065,0.00004025701],"domain_scores_gemma":[0.9995227,0.000143258,0.000172563,0.00002206419,0.00004546957,0.00009391193],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001028893,0.00006422278,0.9892342,0.00001092682,0.00006349049,0.001056281,0.0000744912,0.0001307598,0.004925617,0.00004209713,0.00007892557,0.003290085],"study_design_scores_gemma":[0.00004034464,0.0005448723,0.9942684,0.00000648862,0.0001258216,0.003029241,0.0001236312,0.0006631449,0.000768397,0.00005897263,0.0003650021,0.000005598759],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995325,0.0001084612,0.00005071613,0.00003401824,0.000003583301,0.000003848668,0.00003445454,0.000001361629,0.0002311659],"genre_scores_gemma":[0.9998273,0.00002455728,0.00004141357,0.00001422003,0.000004670977,0.000001210757,0.00003371423,0.000001072708,0.00005185225],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001942146,"threshold_uncertainty_score":0.005170465,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0259598995187916,"score_gpt":0.3057188708231988,"score_spread":0.2797589713044072,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}