{"id":"W2141553911","doi":"10.1091/mbc.e08-07-0759","title":"A Histone Deacetylase 4/Myogenin Positive Feedback Loop Coordinates Denervation-dependent Gene Induction and Suppression","year":2008,"lang":"en","type":"article","venue":"Molecular Biology of the Cell","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":146,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Centre National de la Recherche Scientifique; Muscular Dystrophy Association","keywords":"Myogenin; Biology; HDAC4; Myosin; Denervation; Cell biology; Myogenic regulatory factors; Myogenesis; Histone deacetylase; Myocyte; Endocrinology; Biochemistry; Gene; Histone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002070034,0.0002005217,0.0002067584,0.0000791276,0.0002179313,0.000005669177,0.0002870263,0.0003056029,0.0000135336],"category_scores_gemma":[0.0001177776,0.0001632515,0.000123146,0.0001384406,0.0006126903,0.000005176575,0.0003559923,0.000190715,0.000008398079],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004589606,"about_ca_system_score_gemma":0.0001141232,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001248363,"about_ca_topic_score_gemma":0.00001225115,"domain_scores_codex":[0.9985108,0.0003136811,0.0002740657,0.0004545446,0.0001663881,0.0002804958],"domain_scores_gemma":[0.9990783,0.00001990433,0.0001643752,0.0004672328,0.0001803522,0.0000898515],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001147808,0.0001029258,0.0008135996,0.00001426879,0.00004203986,0.00001222034,0.00007098019,0.00005381622,0.9973831,0.00001771479,0.001094673,0.0002799371],"study_design_scores_gemma":[0.0007678305,0.0002648408,0.001389218,0.00001247454,0.00002375438,0.0001514602,0.00002570757,0.00003460019,0.9966219,0.00005014619,0.0004827199,0.0001753546],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946827,0.002931663,0.001228926,0.0003630685,0.0001910835,0.0003008351,0.00004325599,0.00000918053,0.0002493033],"genre_scores_gemma":[0.9967462,0.0002148543,0.0007332225,0.0001336399,0.00006337455,0.00002374261,0.0001543508,0.00002919131,0.001901439],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002716808,"threshold_uncertainty_score":0.6657203,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009163204017177197,"score_gpt":0.2589559058841472,"score_spread":0.24979270186697,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}