{"id":"W2141553911","doi":"10.1091/mbc.e08-07-0759","title":"A Histone Deacetylase 4/Myogenin Positive Feedback Loop Coordinates Denervation-dependent Gene Induction and Suppression","year":2008,"lang":"en","type":"article","venue":"Molecular Biology of the Cell","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":146,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Centre National de la Recherche Scientifique; Muscular Dystrophy Association","keywords":"Myogenin; Biology; HDAC4; Myosin; Denervation; Cell biology; Myogenic regulatory factors; Myogenesis; Histone deacetylase; Myocyte; Endocrinology; Biochemistry; Gene; Histone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001654454,0.0004860833,0.0003322249,0.0002438052,0.0001449414,0.0002680164,0.0003715793,0.0001798554,0.001195832],"category_scores_gemma":[0.0001106254,0.0002250652,0.0002731968,0.0001327097,0.0003635234,0.0001628862,0.0003916385,0.0003180156,0.0003639378],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006532506,"about_ca_system_score_gemma":0.0002951439,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000869353,"about_ca_topic_score_gemma":0.00222634,"domain_scores_codex":[0.9998482,0.00001711615,0.000007622298,0.00004666019,0.00004377533,0.00003654968],"domain_scores_gemma":[0.9999313,0.000008593241,0.00002229268,0.000009164703,0.00001266427,0.00001593832],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000582997,0.000005006172,0.0001654255,0.0000141566,0.000004332485,0.00002269376,0.000004841009,0.00005418073,0.9983132,0.000139168,0.00003417837,0.001184556],"study_design_scores_gemma":[0.00002915804,0.00009956412,0.006685395,0.000003527119,0.00002491243,0.000105498,0.00002008198,0.001790653,0.9875316,0.0001608126,0.003543517,0.000005255913],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9730107,0.0037846,0.01844977,0.0002107871,0.0001225875,0.00004313032,0.0004255672,0.0005257266,0.003427057],"genre_scores_gemma":[0.9882956,0.001048362,0.005370113,0.00007947253,0.00002212693,0.00003272737,0.0004913969,0.0000462341,0.004614059],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001195832,"threshold_uncertainty_score":0.004739702,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009163204017177197,"score_gpt":0.2589559058841472,"score_spread":0.24979270186697,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}