{"id":"W2141569270","doi":"10.1158/0008-5472.can-08-0249","title":"Maintenance of Intratumoral Androgens in Metastatic Prostate Cancer: A Mechanism for Castration-Resistant Tumor Growth","year":2008,"lang":"en","type":"article","venue":"Cancer Research","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":1412,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Center for Research Resources; Oregon National Primate Research Center; National Cancer Institute; Prostate Cancer Foundation; National Institutes of Health; University of Washington; National Institute of Diabetes and Digestive and Kidney Diseases; U.S. Department of Defense","keywords":"Prostate cancer; Castration; Androgen; Medicine; Prostate; Orchiectomy; Testosterone (patch); Internal medicine; Androgen deprivation therapy; Androgen receptor; CYP17A1; Cancer research; Cancer; Intracrine; Endocrinology; Oncology; Biology; Hormone; Gene; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003182185,0.0002687646,0.0002749602,0.0003754236,0.0001558211,0.0004002131,0.0001823228,0.000132354,0.0006274753],"category_scores_gemma":[0.0001790736,0.0001121727,0.0001960669,0.0001724946,0.0003509693,0.0001715167,0.000156955,0.0004269367,0.0001769861],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000311284,"about_ca_system_score_gemma":0.0002438893,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00107108,"about_ca_topic_score_gemma":0.002024154,"domain_scores_codex":[0.9998344,0.00002675115,0.000008327285,0.00002813027,0.00008285281,0.00001949191],"domain_scores_gemma":[0.9998432,0.00001714865,0.00005649787,0.00001781664,0.00001931173,0.00004597986],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001870094,0.00004579667,0.005803571,0.00005746715,0.00001921532,0.000122181,0.00003316758,0.0001444467,0.9865065,0.0002658418,0.00006210335,0.006752747],"study_design_scores_gemma":[0.0000586978,0.002549107,0.2526245,0.00002183667,0.00009087697,0.00383137,0.0001117513,0.003384013,0.7326676,0.0004019473,0.004233535,0.00002470707],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989925,0.004486987,0.004411662,0.0001782584,0.00001629817,0.00001855714,0.0001448035,0.00008570583,0.0007327122],"genre_scores_gemma":[0.9973774,0.0008605833,0.0009546114,0.00003447659,0.00001109363,0.000006272417,0.0001113986,0.000008141608,0.0006361149],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00107108,"threshold_uncertainty_score":0.002258539,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1079303838449509,"score_gpt":0.4065856309627567,"score_spread":0.2986552471178058,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}