{"id":"W2141602361","doi":"10.1007/s00262-009-0711-x","title":"Soluble HLA/peptide monomers cross-linked with co-stimulatory antibodies onto a streptavidin core molecule efficiently stimulate antigen-specific T cell responses","year":2009,"lang":"en","type":"article","venue":"Cancer Immunology Immunotherapy","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"Terry Fox Research Institute; BC Cancer Agency","funders":"European Commission; Kay Kendall Leukaemia Fund","keywords":"Antigen; T cell; Major histocompatibility complex; CD8; T-cell receptor; MHC restriction; Priming (agriculture); Cytotoxic T cell; CD28; Cell biology; Chemistry; Biology; Antibody; Molecular biology; MHC class I; Immunology; Immune system; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002236758,0.0006197598,0.0003531892,0.000228506,0.0001569704,0.0004915007,0.0002242211,0.0003977993,0.00274636],"category_scores_gemma":[0.0001942537,0.0002475803,0.0002846314,0.0001878832,0.0001824468,0.0001759988,0.0004251054,0.0009792653,0.001348517],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003088203,"about_ca_system_score_gemma":0.0003141647,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000420089,"about_ca_topic_score_gemma":0.0009860942,"domain_scores_codex":[0.999708,0.00005523681,0.00001541152,0.00004219084,0.00006262004,0.0001166511],"domain_scores_gemma":[0.9997954,0.00007502574,0.00002368723,0.00002850204,0.00002054102,0.00005692404],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001033483,0.0000523409,0.0001168843,0.00002012601,0.000005152635,0.00002754725,0.00001061644,0.00006170088,0.9984747,0.00008834839,0.00005464827,0.0009847205],"study_design_scores_gemma":[0.00004793526,0.0003282807,0.001448845,0.000006084812,0.00002028423,0.0001574356,0.00002667897,0.001654451,0.9950033,0.00009281545,0.001209703,0.000004274387],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898774,0.0008867564,0.005055354,0.00007590708,0.00008158752,0.00006858366,0.0001129814,0.00008754183,0.003754034],"genre_scores_gemma":[0.9939536,0.00039934,0.002305634,0.00008199948,0.00003159685,0.00003081586,0.0002408118,0.00002945342,0.002926697],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00274636,"threshold_uncertainty_score":0.00918752,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02508194718086599,"score_gpt":0.3054452392910827,"score_spread":0.2803632921102168,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}