{"id":"W2141602361","doi":"10.1007/s00262-009-0711-x","title":"Soluble HLA/peptide monomers cross-linked with co-stimulatory antibodies onto a streptavidin core molecule efficiently stimulate antigen-specific T cell responses","year":2009,"lang":"en","type":"article","venue":"Cancer Immunology Immunotherapy","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"Terry Fox Research Institute; BC Cancer Agency","funders":"European Commission; Kay Kendall Leukaemia Fund","keywords":"Antigen; T cell; Major histocompatibility complex; CD8; T-cell receptor; MHC restriction; Priming (agriculture); Cytotoxic T cell; CD28; Cell biology; Chemistry; Biology; Antibody; Molecular biology; MHC class I; Immunology; Immune system; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts","insufficient_payload"],"consensus_categories":["metaepi_narrow"],"category_scores_codex":[0.0007596931,0.001337742,0.001588969,0.0007695748,0.001536392,0.0002119244,0.001518871,0.001060749,0.002604288],"category_scores_gemma":[0.00004316156,0.001196598,0.000562171,0.0007131477,0.002354514,0.0005796246,0.0001072585,0.001446463,0.0007288869],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004991963,"about_ca_system_score_gemma":0.0007432871,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003079431,"about_ca_topic_score_gemma":0.00001464644,"domain_scores_codex":[0.9939061,0.0008189224,0.001415289,0.001507667,0.0002298566,0.002122189],"domain_scores_gemma":[0.9959691,0.0005695845,0.0008959154,0.002038151,0.0004474758,0.00007977247],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.03369207,0.0008611709,0.01081064,0.00001723939,0.001524851,0.00005911186,0.002247761,0.000776083,0.934795,0.0001707773,0.002257154,0.01278812],"study_design_scores_gemma":[0.01610843,0.0034285,0.1467828,0.0002207355,0.00005775265,0.000148691,0.0005806682,0.00002499683,0.5864843,0.00005774795,0.2445208,0.00158467],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7434615,0.2523052,0.00029096,0.0002515043,0.001369963,0.001029585,0.0001399246,0.0004787974,0.0006724621],"genre_scores_gemma":[0.9327158,0.05089954,0.0002641266,0.001418025,0.00006591051,0.000167261,0.0002951522,0.0002070779,0.01396707],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3483107,"threshold_uncertainty_score":0.9999374,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02508194718086599,"score_gpt":0.3054452392910827,"score_spread":0.2803632921102168,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}