{"id":"W2141610926","doi":"10.1086/655764","title":"HIV‐1 Reverse Transcriptase Connection Domain Mutations: Dynamics of Emergence and Implications for Success of Combination Antiretroviral Therapy","year":2010,"lang":"en","type":"article","venue":"Clinical Infectious Diseases","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; China Scholarship Council; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Novartis Foundation; Gilead Sciences; GlaxoSmithKline; Bristol-Myers Squibb; National Institute of Allergy and Infectious Diseases; Pfizer; National Institutes of Health; National Science Foundation","keywords":"Resistance mutation; Zidovudine; Lamivudine; Reverse transcriptase; Cart; Medicine; Drug resistance; Virology; Mutation; Reverse-transcriptase inhibitor; Genotype; Antiretroviral therapy; Virus; Viral load; Genetics; Biology; Gene; RNA; Viral disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001036248,0.0001361653,0.000238572,0.0005450072,0.0002647881,0.0007664374,0.000254608,0.0004327424,0.001469629],"category_scores_gemma":[0.008425955,0.0001239344,0.0001677207,0.0004903637,0.0003469163,0.0006336352,0.0002794405,0.0004589685,0.0001934027],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003313096,"about_ca_system_score_gemma":0.000184749,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004662457,"about_ca_topic_score_gemma":0.0005384491,"domain_scores_codex":[0.99949,0.0001403773,0.00004546518,0.0001250794,0.000115579,0.00008342469],"domain_scores_gemma":[0.9922908,0.004212667,0.002315668,0.0003278267,0.0004170775,0.0004360129],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005648355,0.00003877695,0.9817305,0.00001446065,0.0000460953,0.0001609409,0.0001231113,0.000489231,0.001471213,0.0001361368,0.0001189193,0.01510585],"study_design_scores_gemma":[0.00001746804,0.0002175201,0.9937583,0.00001287424,0.00003254666,0.001300568,0.0001511023,0.00325214,0.0005869506,0.0003343813,0.0003274563,0.00000874938],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983267,0.0006880063,0.0002642328,0.00008499199,0.00000191959,0.000005370035,0.00007280109,0.000005905405,0.0005500752],"genre_scores_gemma":[0.9997877,0.00008510891,0.00006025303,0.000005638732,0.000005904186,0.000001379153,0.00002935028,0.000001510706,0.00002294405],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001469629,"threshold_uncertainty_score":0.00548023,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02626529912683625,"score_gpt":0.3596697020952359,"score_spread":0.3334044029683997,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}