{"id":"W2141659194","doi":"10.1158/0008-5472.can-07-1525","title":"Egr-1 Mediates Hypoxia-Inducible Transcription of the <i>NDRG1</i> Gene through an Overlapping Egr-1/Sp1 Binding Site in the Promoter","year":2007,"lang":"en","type":"article","venue":"Cancer Research","topic":"Mechanisms of cancer metastasis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Institute of Environmental Health Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute","keywords":"Molecular biology; Transactivation; Gene knockdown; Transcription factor; Promoter; Biology; Electrophoretic mobility shift assay; Gene expression; Transcription (linguistics); Gene; Binding site; Transfection; Response element; Messenger RNA; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003512739,0.0001535975,0.000174656,0.00009923011,0.000181793,0.00004314618,0.0007483266,0.0001629391,0.00007184225],"category_scores_gemma":[0.0001112034,0.0001014444,0.0001018086,0.0005985126,0.0001947345,0.0000296516,0.0001252958,0.0004020494,0.000005493885],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008891908,"about_ca_system_score_gemma":0.0002367505,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005546645,"about_ca_topic_score_gemma":0.001273802,"domain_scores_codex":[0.9974618,0.000413488,0.0003181819,0.0004581479,0.0007522394,0.0005961456],"domain_scores_gemma":[0.9988467,0.00005202542,0.00008904843,0.000755953,0.0001891739,0.00006707155],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001208269,0.00006284399,0.0008790166,0.00004648532,0.00002575483,0.000003785119,0.001112984,0.00002136469,0.9930431,0.000133417,0.0004905887,0.004059848],"study_design_scores_gemma":[0.0004943213,0.0001975578,0.002017482,0.00005970598,0.00001270435,0.00000560914,0.0005698078,0.000007386164,0.9783157,0.0002710161,0.01792668,0.000121991],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939553,0.003117067,0.0005492055,0.0007798076,0.000281625,0.0006213664,0.0000701699,0.000006229462,0.0006192442],"genre_scores_gemma":[0.9970773,0.001228341,0.000559487,0.000280314,0.000489251,0.0001586717,0.0000403153,0.00003148164,0.000134848],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01743609,"threshold_uncertainty_score":0.4136781,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08997272842241157,"score_gpt":0.3855464968118429,"score_spread":0.2955737683894314,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}