{"id":"W2141659194","doi":"10.1158/0008-5472.can-07-1525","title":"Egr-1 Mediates Hypoxia-Inducible Transcription of the <i>NDRG1</i> Gene through an Overlapping Egr-1/Sp1 Binding Site in the Promoter","year":2007,"lang":"en","type":"article","venue":"Cancer Research","topic":"Mechanisms of cancer metastasis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Institute of Environmental Health Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute","keywords":"Molecular biology; Transactivation; Gene knockdown; Transcription factor; Promoter; Biology; Electrophoretic mobility shift assay; Gene expression; Transcription (linguistics); Gene; Binding site; Transfection; Response element; Messenger RNA; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001233481,0.0002959695,0.0001819766,0.0001313468,0.0001323764,0.0001374789,0.0002086088,0.0001635108,0.0009075424],"category_scores_gemma":[0.00005825731,0.0001613401,0.0003165051,0.00008633269,0.0001753089,0.000107635,0.0001852104,0.0004127678,0.0004055384],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003168124,"about_ca_system_score_gemma":0.0002099648,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005803502,"about_ca_topic_score_gemma":0.0009737678,"domain_scores_codex":[0.9998593,0.00002295493,0.00001062264,0.00003614667,0.00003826498,0.00003265482],"domain_scores_gemma":[0.9999542,0.000005405427,0.00001524141,0.000006971778,0.000006370286,0.00001185347],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002282757,0.000005638232,0.00007059263,0.00001468055,0.000001491948,0.00001525923,0.000006319424,0.00001570001,0.9995466,0.00004517428,0.00001613018,0.0002394745],"study_design_scores_gemma":[0.000007394279,0.00005682303,0.003355233,0.00000514574,0.000008569501,0.000140728,0.00001528531,0.0005310448,0.99354,0.00002392723,0.002314007,0.000002051477],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894992,0.00136394,0.00696016,0.0001091016,0.00003271927,0.00003098171,0.0005738987,0.0000683288,0.0013617],"genre_scores_gemma":[0.9864992,0.0009633807,0.006500307,0.00007820344,0.00001228056,0.00004963873,0.001610863,0.00002427836,0.004261835],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009075424,"threshold_uncertainty_score":0.003036022,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08997272842241157,"score_gpt":0.3855464968118429,"score_spread":0.2955737683894314,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}