{"id":"W2141663708","doi":"10.3390/md403157","title":"Marine Toxins That Target Voltage-gated Sodium Channels","year":2006,"lang":"en","type":"article","venue":"Marine Drugs","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research; Alberta Heritage Foundation for Medical Research","keywords":"Sodium channel; Marine toxin; Gating; Mutagenesis; Biology; Drug discovery; Small molecule; Ion channel; Function (biology); Chemistry; Biochemistry; Computational biology; Biophysics; Toxin; Cell biology; Receptor; Sodium; Mutant","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002362369,0.0003311462,0.000286791,0.00006625387,0.0001126771,0.00004705912,0.0003601969,0.0001979332,0.0008259997],"category_scores_gemma":[0.00004561364,0.0003186961,0.0001624853,0.0001679225,0.00008228864,0.000006421241,0.001054474,0.0001873424,0.0001458998],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003375627,"about_ca_system_score_gemma":0.00005865095,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00112557,"about_ca_topic_score_gemma":0.0002088916,"domain_scores_codex":[0.9982715,0.00005369413,0.0003158051,0.0005799636,0.0002421913,0.0005369102],"domain_scores_gemma":[0.9990698,0.00001439769,0.0001313711,0.0005887927,0.00008555695,0.0001101504],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004642074,0.001676042,0.3395261,0.0001116616,0.0003931377,0.00001552171,0.0001758675,0.0004399041,0.2950357,0.0006299734,0.3435784,0.01795355],"study_design_scores_gemma":[0.001545161,0.0001750165,0.005311476,0.000005143728,0.00002860897,0.00001689465,0.00007037605,0.0002226784,0.4415091,0.0003013415,0.5503248,0.0004894243],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.91757,0.0001288435,0.0009605931,0.0006019628,0.0008237003,0.000458122,0.00003292226,0.0001150902,0.07930879],"genre_scores_gemma":[0.9300117,0.00006065534,0.0015475,0.0003850073,0.001304787,0.0000338122,0.001440319,0.00007213991,0.06514407],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3342146,"threshold_uncertainty_score":0.9999265,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006127014437561521,"score_gpt":0.223293368907575,"score_spread":0.2171663544700135,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}