{"id":"W2141663708","doi":"10.3390/md403157","title":"Marine Toxins That Target Voltage-gated Sodium Channels","year":2006,"lang":"en","type":"article","venue":"Marine Drugs","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research; Alberta Heritage Foundation for Medical Research","keywords":"Sodium channel; Marine toxin; Gating; Mutagenesis; Biology; Drug discovery; Small molecule; Ion channel; Function (biology); Chemistry; Biochemistry; Computational biology; Biophysics; Toxin; Cell biology; Receptor; Sodium; Mutant","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001138992,0.0002086856,0.0002348674,0.0001588422,0.0001402169,0.0002077549,0.0001573263,0.000315757,0.001455217],"category_scores_gemma":[0.0001396999,0.00005135614,0.0001756689,0.0001756384,0.0001490208,0.000171251,0.0001957863,0.0002572354,0.0005267195],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001972129,"about_ca_system_score_gemma":0.0001242751,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003793772,"about_ca_topic_score_gemma":0.0004323422,"domain_scores_codex":[0.9999396,0.00001033378,0.000004930264,0.00001023515,0.00002385838,0.00001115723],"domain_scores_gemma":[0.9999574,0.000009964146,0.000009778916,0.000003116383,0.0000090761,0.00001068207],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001912246,0.00006284958,0.001884711,0.0005986536,0.00003485788,0.0007691081,0.00006900511,0.0003146006,0.9443467,0.002032279,0.0009411534,0.04875483],"study_design_scores_gemma":[0.00004783603,0.001238342,0.01126524,0.0001039687,0.00009958236,0.00469542,0.0001012948,0.0007246308,0.9111408,0.0008717923,0.06969663,0.0000144837],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7373625,0.2046164,0.01845265,0.001250036,0.0005609584,0.0001557271,0.0005893894,0.0003279819,0.03668439],"genre_scores_gemma":[0.8639288,0.1114025,0.008477902,0.0008938814,0.0002109817,0.00007502564,0.000496672,0.00002557509,0.01448848],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001455217,"threshold_uncertainty_score":0.004868209,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006127014437561521,"score_gpt":0.223293368907575,"score_spread":0.2171663544700135,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}