{"id":"W2141674087","doi":"10.1128/aac.01719-09","title":"Cysteamine, the Molecule Used To Treat Cystinosis, Potentiates the Antimalarial Efficacy of Artemisinin","year":2010,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Drug-Induced Hepatotoxicity and Protection","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; McGill University","funders":"Canadian Institutes of Health Research; McGill University","keywords":"Artemisinin; Plasmodium chabaudi; Malaria; Cystinosis; Parasitemia; Plasmodium falciparum; Dihydroartemisinin; Pharmacology; Artesunate; Medicine; Primaquine; Combination therapy; Cysteamine; Immunology; Biology; Internal medicine; Biochemistry; Cysteine; Cystine; Chloroquine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005204118,0.0002214874,0.0002440228,0.00005342267,0.0004930507,0.0000510165,0.0003340127,0.0002717013,0.0003295449],"category_scores_gemma":[0.00003976367,0.0001365442,0.0001204591,0.0002131866,0.0002454797,0.00006067075,0.00006237299,0.0006229102,0.00003415806],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000920143,"about_ca_system_score_gemma":0.00003323676,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001308383,"about_ca_topic_score_gemma":0.00004322411,"domain_scores_codex":[0.9987721,0.0002062158,0.0003033777,0.0002806482,0.0001216812,0.0003159482],"domain_scores_gemma":[0.9992227,0.0002008882,0.0001478288,0.0002643007,0.00006236177,0.00010194],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004338803,0.0003439004,0.008782368,0.0000257497,0.0001119152,0.000003964275,0.001659367,0.00003403106,0.9662238,0.0001462592,0.009605449,0.01262931],"study_design_scores_gemma":[0.002895566,0.000124377,0.04779819,0.00001909372,0.000101576,0.00004001246,0.00004772356,0.000226505,0.8827304,0.00005426134,0.06574546,0.0002168275],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9872534,0.00001408089,0.00008578391,0.01025055,0.0008784787,0.0007869212,0.00004747351,0.00003848275,0.0006447772],"genre_scores_gemma":[0.9908167,0.0001318659,0.00009462176,0.008184741,0.0003827883,0.00001888645,0.00001270432,0.00002568348,0.0003320593],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0834934,"threshold_uncertainty_score":0.5568113,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0618636440382699,"score_gpt":0.3774787061599162,"score_spread":0.3156150621216463,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}