{"id":"W2141680945","doi":"10.1093/toxsci/kfh073","title":"Evaluating the Human Relevance of Chemically Induced Animal Tumors","year":2004,"lang":"en","type":"article","venue":"Toxicological Sciences","topic":"Carcinogens and Genotoxicity Assessment","field":"Biochemistry, Genetics and Molecular Biology","cited_by":164,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Health Canada; U.S. Environmental Protection Agency","keywords":"Relevance (law); Mode of action; Action (physics); Key (lock); Human health; Animal testing; Computer science; Human studies; Table (database); Risk assessment; Risk analysis (engineering); Medicine; Toxicology; Biology; Data mining; Environmental health; Political science; Ecology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007028702,0.00008694347,0.0001098995,0.00001241778,0.000248507,0.00002162373,0.0003883299,0.00007767414,0.00004644323],"category_scores_gemma":[0.0002277794,0.00005065478,0.0000683967,0.0001544154,0.0004642407,0.000003056098,0.0001730277,0.00008361032,0.000002029752],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001767602,"about_ca_system_score_gemma":0.0001021508,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002731458,"about_ca_topic_score_gemma":0.00002889423,"domain_scores_codex":[0.9989772,0.00005056523,0.0001926183,0.0002883105,0.0002724413,0.000218801],"domain_scores_gemma":[0.9996286,0.00002950557,0.00009837352,0.000153965,0.00004361825,0.00004593691],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001492911,0.00006788348,0.000791853,0.000002362998,0.00000405839,8.19522e-7,0.00002093333,0.0003101661,0.9964163,0.001677813,0.00001354186,0.0006792899],"study_design_scores_gemma":[0.0002281513,0.003268125,0.03253988,0.000008041714,0.000005317794,0.000007816218,0.00009838225,0.000033507,0.9621434,0.001471831,0.0001004274,0.00009518092],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975199,0.00009647287,0.00005014661,0.0006081761,0.0000267604,0.0001571147,0.000002321171,0.000007137685,0.001531932],"genre_scores_gemma":[0.9981458,0.000008220222,0.001393742,0.0003245899,0.0000771746,0.0000153684,0.000002188596,0.000002723842,0.00003015186],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03427301,"threshold_uncertainty_score":0.2065642,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09729742384321832,"score_gpt":0.399286374144865,"score_spread":0.3019889503016466,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}