{"id":"W2141768943","doi":"10.1681/asn.v122326","title":"Downregulation of Hepatic Cytochrome P450 in Chronic Renal Failure","year":2001,"lang":"en","type":"article","venue":"Journal of the American Society of Nephrology","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":212,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"","keywords":"Endocrinology; Internal medicine; Phenobarbital; Cytochrome P450; CYP1A2; CYP2E1; Dexamethasone; Downregulation and upregulation; Drug metabolism; Medicine; Chemistry; Biology; Metabolism; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009883519,0.0001627126,0.0006603413,0.0001094826,0.00006661987,0.00000304325,0.0005220144,0.0001492359,0.0002432551],"category_scores_gemma":[0.0000333872,0.0001224619,0.0004845631,0.0005936012,0.001005442,0.00007498715,0.0001097981,0.0007492768,0.00000281328],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001303631,"about_ca_system_score_gemma":0.0002989163,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005556877,"about_ca_topic_score_gemma":0.00003108323,"domain_scores_codex":[0.9978511,0.0006207852,0.0008260707,0.0001321122,0.0002448322,0.0003250892],"domain_scores_gemma":[0.997484,0.0002920105,0.001731784,0.000195981,0.0001963419,0.00009984925],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000421177,0.0001762683,0.003572308,0.00002632775,0.0003192922,0.000007158539,0.0006742812,0.009121438,0.9709458,0.00004899118,0.005991293,0.008695632],"study_design_scores_gemma":[0.004136288,0.0008221335,0.7486221,0.00004299572,0.0004596817,0.0003610768,0.0003305145,0.009182289,0.05452587,0.001331925,0.1799686,0.0002165503],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936413,0.001215661,0.0002298252,0.004534135,0.00009363401,0.0001599626,0.00001216836,0.00000438303,0.0001088859],"genre_scores_gemma":[0.9923801,0.002547862,0.001108114,0.003459687,0.0004275723,0.000003434534,0.000001187605,0.00001444653,0.00005761683],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.91642,"threshold_uncertainty_score":0.4993854,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04922851269049775,"score_gpt":0.388355913755556,"score_spread":0.3391274010650582,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}