{"id":"W2141772678","doi":"10.1007/3-540-31181-5_6","title":"Epigenetics of Complex Diseases: From General Theory to Laboratory Experiments","year":2006,"lang":"en","type":"review","venue":"Current topics in microbiology and immunology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre for Addiction and Mental Health","funders":"","keywords":"Epigenetics; Mendelian inheritance; DNA methylation; Biology; Disease; Context (archaeology); Complex disease; Genetics; Mendelian randomization; Identification (biology); Evolutionary biology; Bioinformatics; Medicine; Gene; Genetic variants; Gene expression; Genotype; Pathology; Ecology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001384214,0.0003437148,0.0009166259,0.0001614288,0.00004354626,0.000007866925,0.0003165308,0.0006044068,0.00002790266],"category_scores_gemma":[0.00006016931,0.0003229064,0.0001463408,0.0001150256,0.0002719394,0.000001814196,0.0003520099,0.0002296584,0.000006832507],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002966843,"about_ca_system_score_gemma":0.0001365087,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001407605,"about_ca_topic_score_gemma":0.00001722762,"domain_scores_codex":[0.9979076,0.0005581653,0.0006548667,0.0005612092,0.00002894242,0.0002892635],"domain_scores_gemma":[0.9991153,0.00005446717,0.0002576731,0.0004605117,0.00006497792,0.00004704584],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000641981,0.0003171864,0.001641987,0.0008963237,0.0003179983,0.000003007389,0.00007301339,0.000006763848,0.1236965,0.0006357027,0.0006469439,0.8717004],"study_design_scores_gemma":[0.0003068324,0.000169254,0.0007276936,0.0003156436,0.000111715,0.000001495574,0.000007262654,3.558191e-7,0.003967021,0.000308216,0.9937806,0.0003039034],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.02940149,0.9679356,0.0004459881,0.000007134518,0.0008295702,0.0003866958,0.0009488509,0.000004968214,0.0000397015],"genre_scores_gemma":[0.0004758705,0.9940666,0.0006183209,0.00002783424,0.0003028671,0.00005711406,0.004304133,0.00002943112,0.0001178553],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9931337,"threshold_uncertainty_score":0.9999223,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03237153823772838,"score_gpt":0.3431929460475858,"score_spread":0.3108214078098575,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}