{"id":"W2141806529","doi":"10.1128/mcb.20.11.4115-4127.2000","title":"Telomere Maintenance in Telomerase-Deficient Mouse Embryonic Stem Cells: Characterization of an Amplified Telomeric DNA","year":2000,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":136,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Terry Fox Research Institute; Institute of Aging","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; National Cancer Institute; National Institutes of Health","keywords":"Telomerase; Telomere; Biology; Embryonic stem cell; Cell biology; Molecular biology; Stem cell; Telomerase reverse transcriptase; Telomere-binding protein; Gene; Genetics; DNA-binding protein; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002799604,0.0003482217,0.0007040249,0.000325802,0.00007114674,0.00001832969,0.0001943831,0.0002742024,0.0002175059],"category_scores_gemma":[0.00001253458,0.0003122328,0.0001216645,0.0005766733,0.0002937212,0.0000835777,0.00004629237,0.000266722,0.00003722272],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005012657,"about_ca_system_score_gemma":0.00009476456,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008364827,"about_ca_topic_score_gemma":0.00001026695,"domain_scores_codex":[0.9976674,0.0002225339,0.0005967675,0.0007286845,0.0001995484,0.0005851216],"domain_scores_gemma":[0.9988858,0.00002527375,0.0001597928,0.0006099662,0.00008570329,0.000233427],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002937882,0.0003486138,0.002355868,0.0001238143,0.00003303245,0.0001588273,0.0002325002,0.00001024863,0.9483364,0.0002325617,0.00000578545,0.04786853],"study_design_scores_gemma":[0.001890357,0.0007259106,0.007638857,0.00008587183,0.00005721811,0.00008503861,0.0001642685,0.0004856985,0.9835236,0.00005076128,0.004895247,0.000397183],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997066,0.0009130588,0.0007093091,0.0001819269,0.00009633996,0.0005416422,0.00004886006,0.00006939637,0.0003734819],"genre_scores_gemma":[0.9971679,0.0007601189,0.0002384085,0.0006720996,0.00003768062,0.00003262223,0.000245028,0.0000513973,0.0007947892],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04747135,"threshold_uncertainty_score":0.999933,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008382606109708368,"score_gpt":0.220985173005501,"score_spread":0.2126025668957926,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}