{"id":"W2141815936","doi":"10.1128/jvi.01888-06","title":"Arginine Methylation of the Human Immunodeficiency Virus Type 1 Tat Protein by PRMT6 Negatively Affects Tat Interactions with both Cyclin T1 and the Tat Transactivation Region","year":2007,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":130,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; McGill University","funders":"Canadian Institutes of Health Research; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Biology; Transactivation; Methylation; Molecular biology; Protein methylation; HIV Long Terminal Repeat; Reporter gene; Gene expression; Methyltransferase; Long terminal repeat; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001133215,0.0002943402,0.0002356408,0.00008989201,0.0001700557,0.0002638097,0.0002250174,0.000235467,0.000932899],"category_scores_gemma":[0.0001513558,0.00014373,0.0002715737,0.00009704912,0.0001882275,0.0001948503,0.0001726204,0.0004961404,0.0003128162],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002551402,"about_ca_system_score_gemma":0.0001398221,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005924953,"about_ca_topic_score_gemma":0.0005492276,"domain_scores_codex":[0.9998128,0.00004514845,0.00002125373,0.00004210133,0.00004730858,0.00003145624],"domain_scores_gemma":[0.9999007,0.00001887181,0.00002892175,0.00001574929,0.000008795135,0.00002690469],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008013126,0.000009558483,0.0001589833,0.00001389888,0.000003284466,0.00002856898,0.0000074324,0.00005275618,0.999087,0.00005199115,0.00001162437,0.0004946911],"study_design_scores_gemma":[0.000006182235,0.00009362343,0.001963456,0.000001658264,0.000007664051,0.0002014737,0.00000846392,0.0009314172,0.9957613,0.00002352708,0.0009984194,0.000002708569],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958408,0.001079065,0.002185802,0.00005951877,0.00002023379,0.000008696298,0.0001585642,0.00005032041,0.0005970325],"genre_scores_gemma":[0.9971074,0.0003237215,0.001189756,0.00001667233,0.000004200525,0.000006207731,0.0002136233,0.00001423557,0.001124048],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000932899,"threshold_uncertainty_score":0.00312084,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006616405144929134,"score_gpt":0.2533997937513421,"score_spread":0.246783388606413,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}