{"id":"W2141815936","doi":"10.1128/jvi.01888-06","title":"Arginine Methylation of the Human Immunodeficiency Virus Type 1 Tat Protein by PRMT6 Negatively Affects Tat Interactions with both Cyclin T1 and the Tat Transactivation Region","year":2007,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":130,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; McGill University","funders":"Canadian Institutes of Health Research; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Biology; Transactivation; Methylation; Molecular biology; Protein methylation; HIV Long Terminal Repeat; Reporter gene; Gene expression; Methyltransferase; Long terminal repeat; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00059629,0.0001062441,0.000170934,0.00006859162,0.0001156417,0.000009062835,0.0001079657,0.0001142387,0.000005649458],"category_scores_gemma":[0.00007131489,0.00006201195,0.00006760574,0.0001663249,0.0002735197,0.00001957842,0.00001595625,0.0002282413,1.856669e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003411677,"about_ca_system_score_gemma":0.00005466239,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003600329,"about_ca_topic_score_gemma":0.0001254284,"domain_scores_codex":[0.9990422,0.0002558902,0.0003200561,0.000125584,0.000137,0.0001193228],"domain_scores_gemma":[0.9989094,0.00006278516,0.0007107404,0.000146791,0.0001463284,0.00002392019],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001757601,0.00005487416,0.0002198869,0.000006999232,0.00008258537,7.145991e-7,0.0002590854,0.001061756,0.9939038,0.0001301519,0.0001066199,0.002415981],"study_design_scores_gemma":[0.002621517,0.001432894,0.01992034,0.00004975668,0.0001041083,0.0001620795,0.000125185,0.000219088,0.9723603,0.0003591555,0.002545018,0.0001006032],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9654704,0.001219095,0.03180953,0.0009759216,0.0001238869,0.0003125193,0.000002155688,0.00000227877,0.00008424604],"genre_scores_gemma":[0.999364,0.0001155053,0.000202573,0.00006206406,0.00007695449,0.000004376499,0.000007796471,0.00001278686,0.0001539346],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03389364,"threshold_uncertainty_score":0.2528774,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006616405144929134,"score_gpt":0.2533997937513421,"score_spread":0.246783388606413,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}