{"id":"W2141825656","doi":"10.1073/pnas.1019441108","title":"Structural basis for pregnenolone biosynthesis by the mitochondrial monooxygenase system","year":2011,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":342,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; Structural Genomics Consortium; University of Toronto","funders":"Knut och Alice Wallenbergs Stiftelse; Karolinska Institutet; Stiftelsen för Strategisk Forskning; Ontario Genomics Institute; Canadian Institutes of Health Research; Ontario Genomics; Genome Canada; Ontario Innovation Trust; Wellcome Trust; GlaxoSmithKline","keywords":"Adrenodoxin; Cholesterol side-chain cleavage enzyme; Pregnenolone; Monooxygenase; Chemistry; Cytochrome P450; Stereochemistry; Heme; Steroid biosynthesis; Cytochrome; Steroid; Biochemistry; Enzyme; Hormone","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001037158,0.000267778,0.0002570841,0.0001189358,0.0004599314,0.0004182268,0.0004152455,0.0003752423,0.002392031],"category_scores_gemma":[0.0002273195,0.0001180981,0.0001937207,0.0001225336,0.0004198144,0.0003044754,0.0003018861,0.0005121983,0.0008984139],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006152394,"about_ca_system_score_gemma":0.0004444632,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009165892,"about_ca_topic_score_gemma":0.0006888805,"domain_scores_codex":[0.9999356,0.00001131833,0.000004185166,0.00001256603,0.0000239017,0.00001236782],"domain_scores_gemma":[0.9999385,0.0000100652,0.00001641681,0.000007152097,0.000009923056,0.00001789586],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006659308,0.0001448049,0.005995501,0.000788737,0.00006818094,0.002868145,0.0003431501,0.01468082,0.8629991,0.08494392,0.001839798,0.02466181],"study_design_scores_gemma":[0.000528003,0.002209703,0.02316367,0.000265308,0.0001484675,0.006397472,0.001137032,0.07634794,0.6222515,0.1038383,0.1635442,0.0001685072],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.924503,0.01599432,0.03178214,0.004154027,0.000401934,0.0001126882,0.0004745529,0.0004449494,0.02213239],"genre_scores_gemma":[0.990133,0.003548783,0.003920509,0.000146725,0.00006549217,0.00001896852,0.0004179311,0.0000117482,0.001736854],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002392031,"threshold_uncertainty_score":0.008002102,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1849263836382589,"score_gpt":0.4017444171117118,"score_spread":0.216818033473453,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}