{"id":"W2141840620","doi":"10.1001/jama.2013.282426","title":"Calcium-Channel Blocker–Clarithromycin Drug Interactions and Acute Kidney Injury","year":2013,"lang":"en","type":"article","venue":"JAMA","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":158,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Western University; St. Michael's Hospital; London Health Sciences Centre; Lawson Health Research Institute; Institute for Clinical Evaluative Sciences","funders":"Canadian Institutes of Health Research","keywords":"Medicine; Clarithromycin; Azithromycin; Amlodipine; Calcium channel blocker; Nifedipine; Internal medicine; Population; Acute kidney injury; Pharmacology; Calcium; Blood pressure; Antibiotics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0003246691,0.000279902,0.0002968166,0.0001548621,0.0003315523,0.00009797731,0.0002546071,0.0001974808,0.00388071],"category_scores_gemma":[0.00006286107,0.0002632094,0.00009921728,0.0001913128,0.0001895415,0.000333923,0.0002254154,0.001070025,0.0008881637],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003234483,"about_ca_system_score_gemma":0.00007802652,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000227493,"about_ca_topic_score_gemma":0.000005690229,"domain_scores_codex":[0.9983333,0.0002776366,0.0003495011,0.0003847773,0.0001412719,0.0005135556],"domain_scores_gemma":[0.9985882,0.0001368942,0.0001177175,0.0002283438,0.0001662399,0.0007625766],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001544971,0.0003660246,0.001969593,0.00003418253,0.0005628586,0.00002886564,0.001230659,0.00002245863,0.3701592,0.0009451929,0.5568939,0.06763251],"study_design_scores_gemma":[0.002589058,0.0000369066,0.009324552,0.00001664468,0.0004111883,0.00007951249,0.0001536219,0.007048851,0.1933535,0.003138599,0.7834011,0.000446462],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9650506,0.0007049688,0.0001523622,0.0218298,0.003130439,0.0005564955,0.0004319974,0.0001380825,0.008005206],"genre_scores_gemma":[0.9684833,0.000895428,0.0003975007,0.02254332,0.0008786759,0.0001638376,0.00005458232,0.00003982264,0.006543551],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2265071,"threshold_uncertainty_score":0.999982,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0596719642737276,"score_gpt":0.4090034394094295,"score_spread":0.3493314751357019,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}